Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI024762-03
Application #
3546703
Study Section
Microbiology and Infectious Diseases Research Committee (MID)
Project Start
1987-06-01
Project End
1990-05-31
Budget Start
1989-06-01
Budget End
1990-05-31
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Tennessee Knoxville
Department
Type
Schools of Veterinary Medicine
DUNS #
City
Knoxville
State
TN
Country
United States
Zip Code
37996
Babu, J S; Nair, S; Kanda, P et al. (1995) Priming for virus-specific CD8+ but not CD4+ cytotoxic T lymphocytes with synthetic lipopeptide is influenced by acylation units and liposome encapsulation. Vaccine 13:1669-76
Nair, S; Buiting, A M; Rouse, R J et al. (1995) Role of macrophages and dendritic cells in primary cytotoxic T lymphocyte responses. Int Immunol 7:679-88
Rouse, R J; Nair, S K; Lydy, S L et al. (1994) Induction in vitro of primary cytotoxic T-lymphocyte responses with DNA encoding herpes simplex virus proteins. J Virol 68:5685-9
Zhou, F; Huang, L (1994) Liposome-mediated cytoplasmic delivery of proteins: an effective means of accessing the MHC class I-restricted antigen presentation pathway. Immunomethods 4:229-35
Banks, T A; Jenkins, F J; Kanangat, S et al. (1994) Vaccination with the immediate-early protein ICP47 of herpes simplex virus-type 1 (HSV-1) induces virus-specific lymphoproliferation, but fails to protect against lethal challenge. Virology 200:236-45
Martin, S; Mercadal, C M; Weir, J P et al. (1993) The proportion of herpes simplex virus-specific cytotoxic T lymphocytes (Tc) that recognize glycoprotein C varies between individual mice and is dependent on the form of immunization. Viral Immunol 6:21-33
Banks, T A; Nair, S; Rouse, B T (1993) Recognition by and in vitro induction of cytotoxic T lymphocytes against predicted epitopes of the immediate-early protein ICP27 of herpes simplex virus. J Virol 67:613-6
Nair, S; Babu, J S; Dunham, R G et al. (1993) Induction of primary, antiviral cytotoxic, and proliferative responses with antigens administered via dendritic cells. J Virol 67:4062-9
Zhou, F; Rouse, B T; Huang, L (1992) Prolonged survival of thymoma-bearing mice after vaccination with a soluble protein antigen entrapped in liposomes: a model study. Cancer Res 52:6287-91
Zhou, F; Rouse, B T; Huang, L (1992) Induction of cytotoxic T lymphocytes in vivo with protein antigen entrapped in membranous vehicles. J Immunol 149:1599-604

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