Project Start
1986-09-30
Project End
1991-07-31
Budget Start
1987-09-30
Budget End
1988-07-31
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Emory University
Department
Type
Schools of Medicine
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Boudinot, F D; Schinazi, R F; Doshi, K J et al. (1993) Pharmacokinetics and metabolism of 3'-azido-2',3'-dideoxy-5-methylcytidine in rhesus monkeys. Drug Metab Dispos 21:855-60
August, E M; Qian, H Y; Birks, E M et al. (1993) Metabolism and mode of selective inhibition of human immunodeficiency virus replication by 3'-azido-2',3'-dideoxy-5-iodouridine and 3'-azido-2',3'-dideoxy-5-bromouridine. Biochem Pharmacol 45:223-30
Schinazi, R F; McMillan, A; Cannon, D et al. (1992) Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine. Antimicrob Agents Chemother 36:2423-31
Schinazi, R F; Boudinot, F D; Ibrahim, S S et al. (1992) Pharmacokinetics and metabolism of racemic 2',3'-dideoxy-5-fluoro-3'-thiacytidine in rhesus monkeys. Antimicrob Agents Chemother 36:2432-8
Weeks, M S; Hill, C L; Schinazi, R F (1992) Synthesis, characterization, and anti-human immunodeficiency virus activity of water-soluble salts of polyoxotungstate anions with covalently attached organic groups. J Med Chem 35:1216-21
Bardos, T J; Schinazi, R F; Ling, K H et al. (1992) Structure-activity relationships and mode of action of 5-mercapto-substituted oligo- and polynucleotides as antitemplates inhibiting replication of human immunodeficiency virus type 1. Antimicrob Agents Chemother 36:108-14
Goudgaon, N M; Schinazi, R F (1991) Activity of acyclic 6-(phenylselenenyl)pyrimidine nucleosides against human immunodeficiency viruses in primary lymphocytes. J Med Chem 34:3305-9
August, E M; Birks, E M; Prusoff, W H (1991) 3'-Deoxythymidin-2'-ene permeation of human lymphocyte H9 cells by nonfacilitated diffusion. Mol Pharmacol 39:246-9
Doong, S L; Tsai, C H; Schinazi, R F et al. (1991) Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues. Proc Natl Acad Sci U S A 88:8495-9
Cretton, E M; Xie, M Y; Bevan, R J et al. (1991) Catabolism of 3'-azido-3'-deoxythymidine in hepatocytes and liver microsomes, with evidence of formation of 3'-amino-3'-deoxythymidine, a highly toxic catabolite for human bone marrow cells. Mol Pharmacol 39:258-66

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