Pathogenesis of Human Papillomaviruses in Vitro

Laimins, Laimonis A.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project--Cooperative Agreements (U01)
• Project #: 5U01AI034637-05
• Application #: 2069800
• Study Section: Special Emphasis Panel (SRC (75))
• Project Start: 1993-09-30
• Project End: 1997-07-31
• Budget Start: 1996-08-01
• Budget End: 1997-07-31
• Support Year: 5
• Fiscal Year: 1996

Institution

• Name: Northwestern University at Chicago
• Department: Microbiology/Immun/Virology
• Type: Schools of Dentistry
• DUNS #: 005436803
• City: Chicago
• State: IL
• Country: United States
• Zip Code: 60611

Publications

Frattini, M G; Hurst, S D; Lim, H B et al. (1997) Abrogation of a mitotic checkpoint by E2 proteins from oncogenic human papillomaviruses correlates with increased turnover of the p53 tumor suppressor protein. EMBO J 16:318-31

Frattini, M G; Lim, H B; Doorbar, J et al. (1997) Induction of human papillomavirus type 18 late gene expression and genomic amplification in organotypic cultures from transfected DNA templates. J Virol 71:7068-72

Frattini, M G; Lim, H B; Laimins, L A (1996) In vitro synthesis of oncogenic human papillomaviruses requires episomal genomes for differentiation-dependent late expression. Proc Natl Acad Sci U S A 93:3062-7

Hummel, M; Lim, H B; Laimins, L A (1995) Human papillomavirus type 31b late gene expression is regulated through protein kinase C-mediated changes in RNA processing. J Virol 69:3381-8