This is the Baylor College of Medicine (BCM)-University of Texas Medical School in Houston (UT) application for Part III of the Women and Infants Transmission Study (WITS). BCM-UT has been an active participant in WITS II endeavors through award of cooperative agreement U01-AI34840-01 in July 1993. Since 1988, BCM-UT has established liaisons with providers who care for a large maternal-infant population infected with human immunodeficiency virus (HIV). These providers make up National Institutes of Health (NIH)-sponsored Pediatric Obstetrical HIV RESEARCH CENTER at BCM and UT. BCM-UT seeks to continue to perform WITS research as part of its coordinated recruitment of HIV-infected mother-infant pairs into natural history, diagnostic, and therapeutic clinical trial programs. By using the combined strengths of other NIH-funded research, including basic science awards, and the facilities of the General Clinical Research Center (GCRC) at the BCM-affiliated Texas Children's Hospital, it will be possible to continue to enroll 50 mother-infant pairs per year into WITS with greatest economy of financial resources. The following research aims are identified for WITS III: (1) to determine material co-factors related to maternal-infant HIV transmission, including assessment of mechanisms and timing of transmission, (2) to evaluate strategies related to success/failure of perinatal intervention including gestational/postnatal antiretroviral therapy, (3) to determine the impact of pregnancy with/without antiretroviral therapy on the natural history of HIV infection among women through the postpartum period, including immunologic and virologic changes in pregnant HIV-infected women (4) to assess acute HIV infection among both infants and women in light of antiretroviral, prophylactic and immune-based therapy, and (5) to assess factors which might predict disease progression among the cohort of HIV infected children in WITS. Subjects will be recruited through the hospital and clinics affiliated with BCM and UT, private pediatricians and obstetricians in the Houston metropolitan area, and the indigent care clinic system maintained by the Harris County Hospital District Authority. Maternal consent will be obtained after the diagnosis of HIV infection has been documented.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI034840-07
Application #
2886870
Study Section
Special Emphasis Panel (ZAI1-MSQ-A (M1))
Program Officer
Hoff, Rodney
Project Start
1993-07-01
Project End
2001-06-30
Budget Start
1999-07-01
Budget End
2000-06-30
Support Year
7
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Pediatrics
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Welles, Seth L; Bauer, Greta R; LaRussa, Philip S et al. (2007) Time trends for HIV-1 antiretroviral resistance among antiretroviral-experienced and naive pregnant women in New York City during 1991 to early 2001. J Acquir Immune Defic Syndr 44:329-35
Bauer, Greta R; Colgrove, Robert C; Larussa, Philip S et al. (2006) Antiretroviral resistance in viral isolates from HIV-1-transmitting mothers and their infants. AIDS 20:1707-12
Colgrove, Robert C; Millet, Amy; Bauer, Greta R et al. (2005) Gag-p6 Tsg101 binding site duplications in maternal-infant HIV infection. AIDS Res Hum Retroviruses 21:191-9
LaMonte, Ashley C; Paul, Mary E; Read, Jennifer S et al. (2004) Persistent parvovirus B19 infection without the development of chronic anemia in HIV-infected and -uninfected children: the Women and Infants Transmission Study. J Infect Dis 189:847-51
Ioannidis, John P A; Tatsioni, Athina; Abrams, Elaine J et al. (2004) Maternal viral load and rate of disease progression among vertically HIV-1-infected children: an international meta-analysis. AIDS 18:99-108
Llorente, Antolin; Brouwers, Pim; Charurat, Manhattan et al. (2003) Early neurodevelopmental markers predictive of mortality in infants infected with HIV-1. Dev Med Child Neurol 45:76-84
Tuomala, Ruth E; Shapiro, David E; Mofenson, Lynne M et al. (2002) Antiretroviral therapy during pregnancy and the risk of an adverse outcome. N Engl J Med 346:1863-70
LaRussa, Philip; Magder, Laurence S; Pitt, Jane et al. (2002) Association of HIV-1 viral phenotype in the MT-2 assay with perinatal HIV transmission. J Acquir Immune Defic Syndr 30:88-94
Read, J S; Tuomala, R; Kpamegan, E et al. (2001) Mode of delivery and postpartum morbidity among HIV-infected women: the women and infants transmission study. J Acquir Immune Defic Syndr 26:236-45
Macmillan, C; Magder, L S; Brouwers, P et al. (2001) Head growth and neurodevelopment of infants born to HIV-1-infected drug-using women. Neurology 57:1402-11

Showing the most recent 10 out of 21 publications