Abstract

The Women and Infants Transmission Study (WITS-II) will enroll HIV-infected pregnant women and their infants into a multicenter, epidemiologic cohort study whose objectives are to answer critical questions relevant to HIV disease during pregnancy, and maternal-infant transmission. In addition, research issues relevant to implementation of therapeutic intervention in this population will be addressed.
The specific aims of WITS II are 1) to assess the effects of pregnancy on maternal HIV progression 2) to determine maternal co-factors related to vertical transmission 3) to evaluate techniques for early diagnosis of infected infants 4) to describe the natural history of HIV disease in infected infants and 5) to assess the feasibility of vaccine trials in this population. WITS II is a continuation of a currently funded study (WITS I). It will utilize core WITS I protocols along with modifications appropriate to the current state of knowledge to gather epidemiologic, medical, and laboratory data. A dedicated specimen repository will provide unique samples for evaluation of innovative early diagnostic techniques as well as for utilization of state of the art lab techniques in answering key research questions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01AI034856-01
Application #
3548130
Study Section
Special Emphasis Panel (SRC (90))
Project Start
1993-07-01
Project End
1997-06-30
Budget Start
1993-07-01
Budget End
1994-06-30
Support Year
1
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Welles, Seth L; Bauer, Greta R; LaRussa, Philip S et al. (2007) Time trends for HIV-1 antiretroviral resistance among antiretroviral-experienced and naive pregnant women in New York City during 1991 to early 2001. J Acquir Immune Defic Syndr 44:329-35
Bauer, Greta R; Colgrove, Robert C; Larussa, Philip S et al. (2006) Antiretroviral resistance in viral isolates from HIV-1-transmitting mothers and their infants. AIDS 20:1707-12
Colgrove, Robert C; Millet, Amy; Bauer, Greta R et al. (2005) Gag-p6 Tsg101 binding site duplications in maternal-infant HIV infection. AIDS Res Hum Retroviruses 21:191-9
LaMonte, Ashley C; Paul, Mary E; Read, Jennifer S et al. (2004) Persistent parvovirus B19 infection without the development of chronic anemia in HIV-infected and -uninfected children: the Women and Infants Transmission Study. J Infect Dis 189:847-51
Gibson, Laura; Piccinini, Giampiero; Lilleri, Daniele et al. (2004) Human cytomegalovirus proteins pp65 and immediate early protein 1 are common targets for CD8+ T cell responses in children with congenital or postnatal human cytomegalovirus infection. J Immunol 172:2256-64
Ioannidis, John P A; Tatsioni, Athina; Abrams, Elaine J et al. (2004) Maternal viral load and rate of disease progression among vertically HIV-1-infected children: an international meta-analysis. AIDS 18:99-108
Poirier, Miriam C; Divi, Rao L; Al-Harthi, Lena et al. (2003) Long-term mitochondrial toxicity in HIV-uninfected infants born to HIV-infected mothers. J Acquir Immune Defic Syndr 33:175-83
Llorente, Antolin; Brouwers, Pim; Charurat, Manhattan et al. (2003) Early neurodevelopmental markers predictive of mortality in infants infected with HIV-1. Dev Med Child Neurol 45:76-84
LaRussa, Philip; Magder, Laurence S; Pitt, Jane et al. (2002) Association of HIV-1 viral phenotype in the MT-2 assay with perinatal HIV transmission. J Acquir Immune Defic Syndr 30:88-94
Read, J S; Tuomala, R; Kpamegan, E et al. (2001) Mode of delivery and postpartum morbidity among HIV-infected women: the women and infants transmission study. J Acquir Immune Defic Syndr 26:236-45

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