The goal of this cooperative multicenter study is to reduce the burden of asthma morbidity among underserved, primarily minority, inner-city children ages 4-12. Broad-based, cost-effective asthma interventions will be designed and evaluated. This application from the Tucson consortium consists of community-based HMOs and investigators from the University of Arizona Health Sciences Center (UAHSC). Unique aspects of this application include a Southwest Mexican-American population and investigators with considerable experience in asthma research and management, monitoring of indoor bioaerosols, and asthma outcome measures. Eligible pediatric patients with moderate to severe asthma will be identified using computerized medical records databases of visits during the previous 24 months to outpatient clinics, urgent care clinics, emergency rooms, and hospitals. Only children from families living in previously identified urban census tracts with a high level of poverty and primarily Hispanic will be eligible for the study. Recruitment into the study will be initiated by phone calls to the child's parents and primary care physician, followed by an interview during a scheduled home visit by a Case Manager. A baseline medical and environmental evaluation will be followed by a standard """"""""core"""""""" intervention (medical therapy, self-care education, and case management) for the remainder of the study. Three months after recruitment, a randomly selected 50 percent sample of the 200 participants will them be chosen for an extensive 24-month environmental intervention. Asthma outcome measures will then be measured and compared between the two groups at 12 and 24 months.
| Pongracic, Jacqueline A; O'Connor, George T; Muilenberg, Michael L et al. (2010) Differential effects of outdoor versus indoor fungal spores on asthma morbidity in inner-city children. J Allergy Clin Immunol 125:593-9 |
| Pongracic, Jacqueline A; Visness, Cynthia M; Gruchalla, Rebecca S et al. (2008) Effect of mouse allergen and rodent environmental intervention on asthma in inner-city children. Ann Allergy Asthma Immunol 101:35-41 |
| O'Connor, George T; Neas, Lucas; Vaughn, Benjamin et al. (2008) Acute respiratory health effects of air pollution on children with asthma in US inner cities. J Allergy Clin Immunol 121:1133-1139.e1 |
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| Gruchalla, Rebecca S; Pongracic, Jacqueline; Plaut, Marshall et al. (2005) Inner City Asthma Study: relationships among sensitivity, allergen exposure, and asthma morbidity. J Allergy Clin Immunol 115:478-85 |
| Kattan, Meyer; Stearns, Sally C; Crain, Ellen F et al. (2005) Cost-effectiveness of a home-based environmental intervention for inner-city children with asthma. J Allergy Clin Immunol 116:1058-63 |
| Wright, Rosalind J; Mitchell, Herman; Visness, Cynthia M et al. (2004) Community violence and asthma morbidity: the Inner-City Asthma Study. Am J Public Health 94:625-32 |
| O'connor, George T; Walter, Michelle; Mitchell, Herman et al. (2004) Airborne fungi in the homes of children with asthma in low-income urban communities: The Inner-City Asthma Study. J Allergy Clin Immunol 114:599-606 |
| Wind, Steven; Van Sickle, David; Wright, Anne L (2004) Health, place and childhood asthma in southwest Alaska. Soc Sci Med 58:75-88 |
| Morgan, Wayne J; Crain, Ellen F; Gruchalla, Rebecca S et al. (2004) Results of a home-based environmental intervention among urban children with asthma. N Engl J Med 351:1068-80 |
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