This application is in response to RFA 86-CA-10, National Collaborative Diagnostic Imaging Trails Project. We have organized a group of institutions to form the Radiologic Diagnostic Oncology Group (RDOG). This institution is a part of that group. The collaborative group will be designed to provide a means whereby efficacy studies on new diagnostic imaging tests can be instituted in a timely fashion and whereby data can be analyzed in an accurate manner. Under the auspices of an operations center and statistical and data management group, we will establish an ongoing mechanism to: optimize image quality across all participating sites; obtain consistent and complete data across participating sites; create a film library to allow derivative studies in subsequent years; and analyze imaging data for clinical effectiveness and potential algorithm development using appropriate analytic techniques. The techniques employed for analysis will be state-of-the-art involving receiver operating characteristic curve analyses; special care will be taken to ensure operating characteristic curve analyses; special care will taken to ensure correction for a number of biases that might preclude accurate data analyses. The application addresses the staging of both lung prostate cancer. The absolute value of plain radiographs, CT and MRI in the staging of patients with non-small cell bronchogenic carcinoma will be determined; the incremental value of MRI over CT will also be assessed. For staging prostate cancer the accuracy of MRI and transrectal sonography will be determined in both absolute and incremental ways.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01CA045205-04S1
Application #
3548966
Study Section
Special Emphasis Panel (SRC (40))
Project Start
1987-09-04
Project End
1992-07-31
Budget Start
1990-09-01
Budget End
1992-07-31
Support Year
4
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Quint, L E; Van Erp, J S; Bland, P H et al. (1991) Prostate cancer: correlation of MR images with tissue optical density at pathologic examination. Radiology 179:837-42
Quint, L E; Van Erp, J S; Bland, P H et al. (1991) Carcinoma of the prostate: MR images obtained with body coils do not accurately reflect tumor volume. AJR Am J Roentgenol 156:511-6