Significant therapeutic inroads have been made in pediatric and gynecologic cancers, but much remains to be discerned about the biology of these malignancies to be applied to their detection, diagnosis and treatment. The goal of the CHTN Pediatric/Gynecologic Division is to provide high quality research tissue specimens to support biomedical research involving pediatric and gynecologic malignancies. Historically, the Division's efforts have centered around pediatric and ovarian cancer with efforts now made to expand to include other important gynecologic (cervical, endometrial) cancers utilizing both snap-frozen and paraffin- embedded tissues. The Division has also expanded its reliance on focused cancer procurement through cooperative groups to include not only the Childrens Cancer Group and gynecologic Oncology Group, but also the Intergroup Rhabdomyosarcoma Study and National Wilms' Tumor Study. A focused effort to identify and track 'liquid tumors' or the pediatric leukemias to make them widely available to investigators is also planned. Furthermore with the emphasis on molecular genetic research in pediatric/gynecologic cancer, procurement of associated host normal somatic tissues, metastatic tumor, blood and sera as well as familial blood for comparative nucleic acid studies is emphasized. These purposes are achieved through the usage of a dual chambered (ambient and deep frozen) Kit which is used in all studies. The Kit is recyclable and has been successfully piloted in 1994. Success of this CHTN Division has been measured by the publication of more than 70 manuscripts in various well-regarded clinical or basic research journals over the last grant cycle. Although uniquely positioned to procure pediatric and gynecologic malignancies for research purposes on a national basis, the CHTN Pediatric/Gynecologic Division effectively integrates with its adult counterparts in the CHTN in yearly operational planning, cross-referencing of investigator needs, a common computer network and in the common goal of procuring high quality tissues for scientifically sound biomedical research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01CA054021-08S1
Application #
2875680
Study Section
Special Emphasis Panel (SRC (A1))
Program Officer
Bledsoe, Marianna
Project Start
1991-01-01
Project End
2001-03-31
Budget Start
1998-09-22
Budget End
1999-03-31
Support Year
8
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Nationwide Children's Hospital
Department
Type
DUNS #
City
Columbus
State
OH
Country
United States
Zip Code
43205
Duan, Fenghai; Smith, Lynette M; Gustafson, Donna M et al. (2012) Genomic and clinical analysis of fusion gene amplification in rhabdomyosarcoma: a report from the Children's Oncology Group. Genes Chromosomes Cancer 51:662-74
Reichek, Jennifer L; Duan, Fenghai; Smith, Lynette M et al. (2011) Genomic and clinical analysis of amplification of the 13q31 chromosomal region in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group. Clin Cancer Res 17:1463-73
Barr, Frederic G; Duan, Fenghai; Smith, Lynette M et al. (2009) Genomic and clinical analyses of 2p24 and 12q13-q14 amplification in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group. Genes Chromosomes Cancer 48:661-72
Morotti, Raffaella A; Nicol, Kathleen K; Parham, David M et al. (2006) An immunohistochemical algorithm to facilitate diagnosis and subtyping of rhabdomyosarcoma: the Children's Oncology Group experience. Am J Surg Pathol 30:962-8
Davies, S M; Robison, L L; Buckley, J D et al. (2000) Glutathione S-transferase polymorphisms in children with myeloid leukemia: a Children's Cancer Group study. Cancer Epidemiol Biomarkers Prev 9:563-6
Wu, H; Devi, R; Malarkey, W B (1996) Expression and localization of prolactin messenger ribonucleic acid in the human immune system. Endocrinology 137:349-53