Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01CA063200-03
Application #
2104920
Study Section
Special Emphasis Panel (SRC (62))
Project Start
1994-06-03
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Hirota, Haruyo; Gosky, David; Berger, Nathan A et al. (2002) Interference with topoisomerase IIalpha potentiates melphalan cytotoxicity. Int J Oncol 20:311-8
Dowlati, A; Levitan, N; Gordon, N H et al. (2001) Phase II and pharmacokinetic/pharmacodynamic trial of sequential topoisomerase I and II inhibition with topotecan and etoposide in advanced non-small-cell lung cancer. Cancer Chemother Pharmacol 47:141-8
Chatterjee, S; Berger, N A (2000) X-ray-induced damage repair in exponentially growing and growth arrested confluent poly(adenosine diphosphate-ribose) polymerase-deficient V79 chinese hamster cell line. Int J Oncol 17:955-62
Rose, P G; Gordon, N H; Fusco, N et al. (2000) A phase II and pharmacokinetic study of weekly 72-h topotecan infusion in patients with platinum-resistant and paclitaxel-resistant ovarian carcinoma. Gynecol Oncol 78:228-34
Whitacre, C M; Zborowska, E; Willson, J K et al. (1999) Detection of poly(ADP-ribose) polymerase cleavage in response to treatment with topoisomerase I inhibitors: a potential surrogate end point to assess treatment effectiveness. Clin Cancer Res 5:665-72
Belfi, C A; Chatterjee, S; Gosky, D M et al. (1999) Increased sensitivity of human colon cancer cells to DNA cross-linking agents after GRP78 up-regulation. Biochem Biophys Res Commun 257:361-8
He, J; Whitacre, C M; Xue, L Y et al. (1998) Protease activation and cleavage of poly(ADP-ribose) polymerase: an integral part of apoptosis in response to photodynamic treatment. Cancer Res 58:940-6
Whitacre, C M; Berger, N A (1997) Factors affecting topotecan-induced programmed cell death: adhesion protects cells from apoptosis and impairs cleavage of poly(ADP-ribose)polymerase. Cancer Res 57:2157-63