Abstract

Cancers linked to infection by HIV are increasing. As survival in the immunodeficient AIDS population increases, the number of these tumors will increase. The University of Miami/Jackson Memorial Medical Center (UM/JMH) is the second largest medical center in the country and is consistently among the top 3 medical centers in numbers of AIDS patients. At our institution, AIDS related lymphoma is the most commonly diagnosed hematologic malignancy. We have considerable clinical and diagnostic experience in other retroviral cancers. Our cachement area is South Florida, the Caribbean basin, Central and South America. We describe in the following proposal what our center offers to the AIDS related malignancy clinical trials consortium. Resources available for pathological diagnosis, referral, treatment and followup of patients with HIV related cervical cancer, Kaposi's sarcoma and non-Hodgkin's lymphoma are discussed. We also summarize the current clinical and basic research as well as data management system at our medical center. Based on previous experience, we estimate the 35 to 40 patients with the above mentioned diseases will be available yearly for approved clinical trials. Residual tissue from diagnostic procedures performed on these patients will be entered into the existing AIDS malignancy tissue consortium.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01CA070058-04
Application #
2748837
Study Section
Special Emphasis Panel (SRC (09))
Program Officer
Wu, Roy S
Project Start
1995-09-30
Project End
1999-07-31
Budget Start
1998-08-01
Budget End
1999-07-31
Support Year
4
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of Miami School of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33146

  Publications

Lin, Lan; Lee, Jeannette Y; Kaplan, Lawrence D et al. (2009) Effects of chemotherapy in AIDS-associated non-Hodgkin's lymphoma on Kaposi's sarcoma herpesvirus DNA in blood. J Clin Oncol 27:2496-502
Ratner, Lee; Harrington, William; Feng, Xuan et al. (2009) Human T cell leukemia virus reactivation with progression of adult T-cell leukemia-lymphoma. PLoS One 4:e4420
Xia, Tianli; O'Hara, Andrea; Araujo, Iguaracyra et al. (2008) EBV microRNAs in primary lymphomas and targeting of CXCL-11 by ebv-mir-BHRF1-3. Cancer Res 68:1436-42
Gualco, Gabriela; Bacchi, Carlos E (2008) B-cell and T-cell lymphomas of the breast: clinical--pathological features of 53 cases. Int J Surg Pathol 16:407-13
Gualco, Gabriela; van den Berg, Anke; Koopmans, Sicco et al. (2008) Autoimmune lymphoproliferative syndrome in a patient with a new minimal deletion in the death domain of the FAS gene. Hum Pathol 39:137-41
Brinker, Brett T; Krown, Susan E; Lee, Jeannette Y et al. (2008) Phase 1/2 trial of BMS-275291 in patients with human immunodeficiency virus-related Kaposi sarcoma: a multicenter trial of the AIDS Malignancy Consortium. Cancer 112:1083-8
Sampaio, Julio; Brites, Carlos; Araujo, Iguaracyra et al. (2007) AIDS related malignancies in Brazil. Curr Opin Oncol 19:476-8
Ramos, Juan Carlos; Ruiz Jr, Phillip; Ratner, Lee et al. (2007) IRF-4 and c-Rel expression in antiviral-resistant adult T-cell leukemia/lymphoma. Blood 109:3060-8
Dezube, Bruce J; Krown, Susan E; Lee, Jeannette Y et al. (2006) Randomized phase II trial of matrix metalloproteinase inhibitor COL-3 in AIDS-related Kaposi's sarcoma: an AIDS Malignancy Consortium Study. J Clin Oncol 24:1389-94
Kaplan, Lawrence D; Lee, Jeannette Y; Ambinder, Richard F et al. (2005) Rituximab does not improve clinical outcome in a randomized phase 3 trial of CHOP with or without rituximab in patients with HIV-associated non-Hodgkin lymphoma: AIDS-Malignancies Consortium Trial 010. Blood 106:1538-43

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