? ? This application proposes the analysis of trends in prostate cancer incidence and mortality using a MISCAN prostate cancer model representative of US conditions. The model should combine evidence obtained in the European randomized study of screening for prostate cancer (ERSPC) with estimates of prostate cancer epidemiology, intervention efforts and treatment of prostate cancer in the US. ? ? The model should correctly predict recent trends in incidence and mortality, and quantify the contributions of prostate-specific antigen (PSA) screening and developments in treatment to these trends. Moreover the model should quantify the tradeoff between morbidity caused by interventions like PSA screening or new treatments, and the realized reductions in mortality. Finally the model will be used to identify optimal screening and treatment strategies. ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01CA115996-03
Application #
7285698
Study Section
Special Emphasis Panel (ZCA1-SRRB-K (M1))
Program Officer
Feuer, Eric J
Project Start
2005-09-13
Project End
2009-08-31
Budget Start
2007-09-24
Budget End
2008-08-31
Support Year
3
Fiscal Year
2007
Total Cost
$180,067
Indirect Cost
Name
Erasmus Medical Center
Department
Type
DUNS #
411761687
City
Rotterdam
State
Country
Netherlands
Zip Code
3015 -GE