Improvingthe efficiencyof surveillancefor healthcare-associatedinfections,antimicrobialresistance,and otheradverse eventsbyoptimizingavailableelectronichealthinformationsystemsprovidesthecapacityfor facilitiestofocus lesson datacollectionandmore on improvingprocessesand outcomes.This may be _articuladytrue in smallcommunityhospitalswhere staffingandotherresourcesare limited. Enhanced .=lectronicsurveillancealone,however,is notsufficientto accomplishthesepreventiongoals. Acquisition andapplicationof performanceimprovementskillsandtoolsvia multidisciplinareyducationalmodesare also required. Leveragingthe increasedcapacityof combiningelectronicsurveillancewith collaborative neh,:orkingto implementenhancementsis thefocusof the OhioState HealthNetworkInfectionControl Collaborative(OSHNICC). The OSHNICC is builtonthe foundationof the OhioState UniversityHealth System (OSUHS) ('the supportfacilities'),withits highlyintegratedelectronichealthinformationsystem, combinedwith the existingOhioState HealthNetwork(OHSN). OHSN hasfor >10 yearselectronicallyand operationallylinkedOSUHS with severaloutlyingreferral communitiesof varyingsizes(=theoutreach facilities').The existingOSU InformationWarehouse(IW), a richrepositoryof healthinformation,willbe optimizedfor surveillancebysystematicretrospectiveidentificationof reliablesurrogatemarkersfor targeted events,retrospedivecomparisonof electronicwithtraditionalsurveillancefor accuracy,and proposective validationof surveillancemethodolgyfor accuracyand costefficiency. The existingelectronicinterface behveenOSUHS andoutreachfacilitieswillbe usedto expandelectronicsurveillancecapabilitytothese facilities. Concurrently,organized multifacetedcollaborationto improveinfectioncontrolprocessin OSHNICC faciltieswill be conductedwithstandardizedlongitudinaml onitoringof processand outcome measuresas the metric for success. Enhancedelectronicsurveillancefor targeted pathogenswith antimicrobial resistancewill be institutedacrossthe entirenetworkwithrapidepidemiologicand molecular characterizationof transmission.Collaborativeinterventionsto improvebothprocessandoutcomeswillbe tested_,;Athinthisne_h'_' orkusinga grouprandomizationstudydesign.The economicimpactof all phasesof the init_tiath/ewill be estimated. P.-_OPJ2.A.NCE SFFE(S) (o_an_-.atJonc.ity, state) The Ohio State Unk,ersity, Columbus,OH Bamesville Hospital,Bamesville,OH Bamesville Health Care Center, Barnesville,OH Monroe CountyCare Center, Bamesville,OH Madison County Hospital,London,OH Arbors at London,London,OH WoodsfieldNursingand RehabilitationCenter,Woodsfield,OH WyandotMemorial Hospital,Upper Sandusky,OH FairhavenCommunity,UpperSandusky,OH Wyandot Manor, Upper Sandusky, OH Mary Rutan Hospital, Bellefontaine, OH LoganAcres, Bellefontaine, OH BucyrusCommunityHospital,Bucyrus,OH Altercare of Bucyrus,Bucyrus,OH Heartlandof Bucyrus,Bucyrus,OH PHS 3_S(R_#. C'_.'34) Page 2_ Form Page 2 P,_.,.._.a!I,,'_est_jat:dProgramDirector(Last, First, Middle): Stevenson, Kurt Brown KEY PERSO._._-EL See..i:_='m_,c,-ts.Use conb'nuaEonpages as needed to provide the requiredinformation in the format shown below. S_a_v,'_hPL. '-P_..alI,,'w?s'_atcr.Us'.a,q?_er key personnelin alphabeticalorder,lastname firsL t_a.,'_e eRA Commons User Name Organization Roleon Project Stevenson, Kurt Brown INF_55CNTRL Ohio State University Principal Investigator Caswe11R, obert J. Ohio State University Co-Investigator Jarjoura, David Ohio State University Co-lnvestigator Kamal, Jyoti Ohio State University Co-Investigator Lemeshow, Stanley Ohio State University Co-Investigator Mangino, Julie Ohio State University Co-Investigator Murray, David Ohio State University Co-Investigator Pancholi, Preeti Ohio State University Co-Investigator Wang, Shu-Hua Ohio State University Co-Investigator OTHER SIG,_'_FICANTCONTRIBUTORS t'&me Organization Role on Project Brady, Michael Columbus Children's Hospital Technical advisor-Resistance Saltz, Joel H. Ohio State University Technical advisor- Inforrnatics Human Embryonic Stem Ceils [] No [] Yes tfL%eproposedprojectInvolveshumanembryonicstem cells, list below the registrationumberof thespecificcell line(s)from the followinglist: h.'tD:llstemce!Is.n_h.aovlreaistry_nde?.asD. Use conEnuationpages as needed. Ifa s:>e'_..,I:LneC=L""""""""z""""""""l,:cetre.'_-enc_dat_ _Emei.ncludea statementhatonefromtheRegistrywill beused. C,e_lUne Disclosure Pen'nission Statement. App_cabTeto SBIR/STTR Only. See SBIPJSTTRinstructions. [] Yes [] No PHS 3_3 (Re-,,.09..'34) Page3-- Form Page 2-continued Numbetrhefoflowingpagesconsecuth'etfhyroughout theapplicaSonD.onotusesufSxesuchas4a,4b. P_-.,._,a_I:w-est_gator/ProgramDirector(Last. First, Middle): Stevenson, Kurt Brown The r.a..me?f t,hepr_'_cipailnvest}gatorlprogramdirector must be provided at the top of each pdnted page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page.................................................................................................................................................. 1 Description,

Agency
National Institute of Health (NIH)
Institute
National Center for Infectious Diseases (CID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01CI000328-02
Application #
7185161
Study Section
Special Emphasis Panel (ZCI1-TYM (10))
Program Officer
Llata, Eloisa
Project Start
2006-02-01
Project End
2011-01-31
Budget Start
2007-03-01
Budget End
2008-03-14
Support Year
2
Fiscal Year
2007
Total Cost
$391,149
Indirect Cost
Name
Ohio State University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
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Dubberke, Erik R; Nyazee, Humaa A; Yokoe, Deborah S et al. (2012) Implementing automated surveillance for tracking Clostridium difficile infection at multiple healthcare facilities. Infect Control Hosp Epidemiol 33:305-8
Yokoe, Deborah S; Khan, Yosef; Olsen, Margaret A et al. (2012) Enhanced surgical site infection surveillance following hysterectomy, vascular, and colorectal surgery. Infect Control Hosp Epidemiol 33:768-73
Wang, Shu-Hua; Khan, Yosef; Hines, Lisa et al. (2012) Methicillin-resistant Staphylococcus aureus sequence type 239-III, Ohio, USA, 2007-2009. Emerg Infect Dis 18:1557-65
Kasper, Amelia M; Nyazee, Humaa A; Yokoe, Deborah S et al. (2012) A multicenter study of Clostridium difficile infection-related colectomy, 2000-2006. Infect Control Hosp Epidemiol 33:470-6
Schwartz, David N; Evans, R Scott; Camins, Bernard C et al. (2011) Deriving measures of intensive care unit antimicrobial use from computerized pharmacy data: methods, validation, and overcoming barriers. Infect Control Hosp Epidemiol 32:472-80
Dubberke, Erik R; Butler, Anne M; Nyazee, Humaa A et al. (2011) The impact of ICD-9-CM code rank order on the estimated prevalence of Clostridium difficile infections. Clin Infect Dis 53:20-5
Hota, Bala; Lin, Michael; Doherty, Joshua A et al. (2010) Formulation of a model for automating infection surveillance: algorithmic detection of central-line associated bloodstream infection. J Am Med Inform Assoc 17:42-8
Dubberke, Erik R; Butler, Anne M; Yokoe, Deborah S et al. (2010) Multicenter study of surveillance for hospital-onset Clostridium difficile infection by the use of ICD-9-CM diagnosis codes. Infect Control Hosp Epidemiol 31:262-8
Dubberke, Erik R; Butler, Anne M; Yokoe, Deborah S et al. (2010) Multicenter study of Clostridium difficile infection rates from 2000 to 2006. Infect Control Hosp Epidemiol 31:1030-7

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