The purpose of this application is to serve as a Collaborative Treatment Site for the NIDA Collaborative Study to compare three forms of psychosocial treatment in ambulatory cocaine abusers: 1) Supportive-expressive psychotherapy, 2) Cognitive-behavioral psychotherapy, and 3) Drug counseling. Patients will be randomized to one of these three forms of therapy in addition to receiving standard drug counseling. The interaction between patient characteristics (e.g., sociodemographic characteristics, substance use history, psychiatric status), type of therapy, and treatment outcome will also be addressed. In addition to this major study, a substudy will be performed to characterize more clearly the process of relapse and recovery in cocaine abusers. The substudy will examine three specific dimensions of this process by addressing the following questions. 1. What abstinence symptoms do patients experience after stopping cocaine use? Are abstinence symptoms similar in inpatients and outpatients? 2. Does the degree of motivation for treatment correlate with treatment retention and/or outcome? What is the interaction between motivation, specific forms of therapy, and treatment outcome? 3. What is the nature of self-help group activities in which cocaine abusers participate? Does the frequency of attendance and/or degree of participation correlate with overall treatment outcome? Patients seeking treatment for cocaine use disorders at the outpatient program of the Alcohol and Drug Abuse Treatment Center of McLean Hospital and the Chemical Dependence Unit (West End Group Practice) of the Massachusetts General Hospital will be recruited for this study. Subjects will receive (a) drug counseling, and (b) one of the three aforementioned forms of psychotherapy, to which they will be randomly assigned. Study subjects will periodically be interviewed and complete questionnaires to monitor their progress, cocaine abstinence symptoms, motivation and attitude toward treatment, and participation in self-help activities. Urine toxicological screens and breathalyzer tests will also be performed to monitor drug and alcohol use. This study aims to study the efficacy of these three commonly used forms of therapy in the treatment of patients with cocaine use disorders.
| Stulz, Niklaus; Thase, Michael E; Gallop, Robert et al. (2011) Psychosocial treatments for cocaine dependence: the role of depressive symptoms. Drug Alcohol Depend 114:41-8 |
| Stulz, Niklaus; Gallop, Robert; Lutz, Wolfgang et al. (2010) Examining differential effects of psychosocial treatments for cocaine dependence: an application of latent trajectory analyses. Drug Alcohol Depend 106:164-72 |
| Najavits, Lisa M; Lester, Kristin M (2008) Gender differences in cocaine dependence. Drug Alcohol Depend 97:190-4 |
| Gallop, Robert J; Crits-Christoph, Paul; Ten Have, Thomas R et al. (2007) Differential transitions between cocaine use and abstinence for men and women. J Consult Clin Psychol 75:95-103 |
| Weiss, Roger D; Griffin, Margaret L; Gallop, Robert J et al. (2005) The effect of 12-step self-help group attendance and participation on drug use outcomes among cocaine-dependent patients. Drug Alcohol Depend 77:177-84 |
| Siqueland, Lynne; Crits-Christoph, Paul; Barber, Jacques P et al. (2004) What aspects of treatment matter to the patient in the treatment of cocaine dependence? J Subst Abuse Treat 27:169-78 |
| Crits-Christoph, Paul; Gibbons, Mary Beth Connolly; Barber, Jacques P et al. (2003) Mediators of outcome of psychosocial treatments for cocaine dependence. J Consult Clin Psychol 71:918-25 |
| Woody, George E; Gallop, Robert; Luborsky, Lester et al. (2003) HIV risk reduction in the National Institute on Drug Abuse Cocaine Collaborative Treatment Study. J Acquir Immune Defic Syndr 33:82-7 |
| Siqueland, Lynne; Crits-Christoph, Paul; Gallop, Bob et al. (2002) Who starts treatment: engagement in the NIDA collaborative cocaine treatment study. Am J Addict 11:10-23 |
| Siqueland, Lynne; Crits-Christoph, Paul; Gallop, Robert et al. (2002) Retention in psychosocial treatment of cocaine dependence: predictors and impact on outcome. Am J Addict 11:24-40 |
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