The broad, long-term objective of the parent grant (U01 DA040219) is to reduce prevalence of prescription stimulant medication (PSM) misuse among college students, through development and testing of efficacious and cost-effective personalized feedback interventions (PFI). The current supplement proposes to advance efforts to combat the opioid crisis in the United States, particularly among college students, through documenting perceived norms of non-medical use of prescription opioid pain relievers (NPO) and the relationship to actual NPO, assess the relationship between perceived risks, consequences, and use of NPO, explore the impact of media attention on perceived norms and risks, document comorbid substance use with NPO, and develop and pilot test a brief NPO intervention. Both this supplement and the parent grant involve collaboration of 3 research teams with unique strengths to address this problem. Dr. Arria?s College Life Study is one of the largest and most comprehensive studies of PSM in college students. The University of Washington (Geisner, Kilmer) are pioneers in developing and adapting screening and brief Personalized Feedback Interventions (PFI) for a range of addictive behaviors. The University at Albany (Cimini) is nationally recognized for implementing cutting edge interventions into ?real-world? campus health and counseling settings. This team has been working together to develop and test a brief PFI for non-medical use of one class of prescription medications ? stimulants. Thus, we have gained experience that will apply readily to development of similar content for another class of prescription medications: NPO. Study 3 of the parent grant will is a RCT of PFI for stimulants, and thus will allow for an ideal setting to pilot the new NPO materials. The supplement also addresses several gaps in the literature on NPO, including assessment of risk factors such as normative perceptions and risk perception, building on the parent aims.
Aims of this supplemental research directly relate to Aims of the parent grant and include: 1) Document perceived norms for NPO, and the extent to which norms are misperceived relative to actual use. Further, evaluate the relationship between misperceived norms and actual NPO both concurrently and prospectively among individuals with Non-medical use of Prescription Stimulants (NPS). 2) Assess perceived risks and actual experienced consequences of NPO, and the extent to which perceived risks vary by past NPO and predict future NPO and consequences. 3) Evaluate the extent to which self-reported exposure to media descriptions (e.g., descriptions of a ?crisis? and/or ?epidemic?), access to opioids, and costs are related to perceived descriptive norms and perceived risks of NPO. 4) Document comorbidity between NPO, NPS and other substance use, particularly cannabis and alcohol. Understand the extent to which relationships between perceived norms, perceived risks, and NPO use are moderated by other substance use. 5) Develop and pilot-test an NPO brief intervention module to address this comorbidity among college students with NPS.

Public Health Relevance

Non-medical use of prescription opioids (NPO) is a serious public health problem, associated with a wide range of negative consequences including but not limited to overdose fatalities. Young adults are at high risk for NPO, and although college students are at lower risk than non-college-attending peers, college students are at high risk for prescription stimulant misuse (PSM), and among students with PSM, NPO is extremely common. The current supplement aims to assess rates, norms, and risk perception of NPO in a large sample of college students, and develop a brief personalized feedback module addressing NPO for students who engage in PSM, in order to address this serious comorbidity and reduce rates of NPO in this population.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01DA040219-04S1
Application #
9710020
Study Section
Special Emphasis Panel (ZDA1)
Program Officer
Crump, Aria
Project Start
2015-09-01
Project End
2020-05-31
Budget Start
2018-06-01
Budget End
2019-05-31
Support Year
4
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Washington
Department
Psychiatry
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Chen, Julia Cen; Green, Kerry M; Arria, Amelia M et al. (2018) Prospective predictors of flavored e-cigarette use: A one-year longitudinal study of young adults in the U.S. Drug Alcohol Depend 191:279-285
Arria, Amelia M; Geisner, Irene M; Cimini, M Dolores et al. (2018) Perceived academic benefit is associated with nonmedical prescription stimulant use among college students. Addict Behav 76:27-33
Ross, Melissa M; Arria, Amelia M; Brown, Jessica P et al. (2018) College students' perceived benefit-to-risk tradeoffs for nonmedical use of prescription stimulants: Implications for intervention designs. Addict Behav 79:45-51
Arria, Amelia M; DuPont, Robert L (2018) Prescription Stimulant Use and Misuse: Implications for Responsible Prescribing Practices. Am J Psychiatry 175:707-708
Arria, Amelia M; Caldeira, Kimberly M; Vincent, Kathryn B et al. (2017) Do college students improve their grades by using prescription stimulants nonmedically? Addict Behav 65:245-249