Adolescence is a critical neurodevelopmental period that is associated with dramatic increases in rates of substance use. Identifying predictors of substance use and its effects on child and adolescent development is critically important, as substance-related decrements incurred during ongoing maturation could have long- lasting effects on brain functioning and behavioral, health, and psychological outcomes. This Research Project Site application from the University of Michigan and University of Florida is in response to RFA-DA-15-015, as part of the ABCD-USA Consortium (9/13) to prospectively determine the neurodevelopmental and behavioral effects of substance use on children and adolescents. A representative community sample of 975 9-10 year olds will be recruited as part of this application, contributing to the sample of 11,111 to be collected from 11 total sites across the ABCD-USA Consortium. All participants will undergo a comprehensive baseline assessment, including state-of-the-art brain imaging, comprehensive neuropsychological testing, and extensive assessment of substance use patterns and mental health functioning. These comprehensive assessments will occur at 2-year follow-up intervals, with intermediate assessments of functioning and substance use at 6- month intervals. The brain, behavioral, psychological, social, genetic, and environmental data collected during the course of this project will elucidate: 1) the effects of substance use patterns on the adolescent brain; 2) the effects of substance use on behavioral and health outcomes; 3) the bidirectional relationship between psychopathology and substance use patterns; 4) the effects of individual genetic, behavioral, neurobiological, and environmental differences on risk profiles and substance use outcomes; and 5) the ?gateway interactions? between use of different substances. Elements Unique to this Site: This hub's Research Project application leverages site-specific expertise to address two aims focused on the identification of risk and resilience factors for adolescent substance use. Using Mental cutting-edge, analyses), integrated characterized substance interventions baseline data categorized into distinct domains ( De mographic, Cognitive, Health, Personality, Life Stressors Family History/Genetics, Environmental, and Brain), we will use multi-stage analytic methods involving data reduction within each domain (e.g., latent variable identification of etiologically-distinct subgroups (e.g., community detection), and the construction of multi-modal predictive models (e.g., regularized regression). This approach will delineate subgroups by distinct profiles of risk and resilience. This approach is essential for informing outcomes of use during adolescence, which will ultimately inform the development of more and clarify the toxic effects of exposure on adolescent brain, health, and cognition. , efficacious

Public Health Relevance

The ABCD-USA Consortium will use multimodal brain imaging, cognitive and clinical assessments, bioassays, mobile monitoring, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning in 11,111 adolescents followed over 10 years to determine the effects of substance use on adolescent brain and cognitive development. Our 6/13 ABCD-USA Consortium: Research Project will recruit and assess 1100 youth age 9-10 at project entry. In addition to contributions to the overall consortium, our U01 will specifically focus on disentangling risk markers from consequences of adolescent substance use.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01DA041148-04S1
Application #
9736131
Study Section
Program Officer
Deeds, Bethany
Project Start
2015-09-30
Project End
2020-05-31
Budget Start
2018-06-01
Budget End
2019-05-31
Support Year
4
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Physiology
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Walsh, Jeremy J; Barnes, Joel D; Cameron, Jameason D et al. (2018) Associations between 24 hour movement behaviours and global cognition in US children: a cross-sectional observational study. Lancet Child Adolesc Health 2:783-791
Greene, Deanna J; Koller, Jonathan M; Hampton, Jacqueline M et al. (2018) Behavioral interventions for reducing head motion during MRI scans in children. Neuroimage 171:234-245
Zucker, Robert A; Gonzalez, Raul; Feldstein Ewing, Sarah W et al. (2018) Assessment of culture and environment in the Adolescent Brain and Cognitive Development Study: Rationale, description of measures, and early data. Dev Cogn Neurosci 32:107-120
Casey, B J; Cannonier, Tariq; Conley, May I et al. (2018) The Adolescent Brain Cognitive Development (ABCD) study: Imaging acquisition across 21 sites. Dev Cogn Neurosci 32:43-54
Barch, Deanna M; Albaugh, Matthew D; Avenevoli, Shelli et al. (2018) Demographic, physical and mental health assessments in the adolescent brain and cognitive development study: Rationale and description. Dev Cogn Neurosci 32:55-66
Luciana, M; Bjork, J M; Nagel, B J et al. (2018) Adolescent neurocognitive development and impacts of substance use: Overview of the adolescent brain cognitive development (ABCD) baseline neurocognition battery. Dev Cogn Neurosci 32:67-79
Feldstein Ewing, Sarah W; Chang, Linda; Cottler, Linda B et al. (2018) Approaching Retention within the ABCD Study. Dev Cogn Neurosci 32:130-137
Dosenbach, Nico U F; Koller, Jonathan M; Earl, Eric A et al. (2017) Real-time motion analytics during brain MRI improve data quality and reduce costs. Neuroimage 161:80-93
Grayson, David S; Fair, Damien A (2017) Development of large-scale functional networks from birth to adulthood: A guide to the neuroimaging literature. Neuroimage 160:15-31