Characterization and Treatment of Category III Prostatitis Background: Chronic abacterial prostatitis and prostatodynia (NIH Category III), remains a frustrating enigma for North American physicians and patients. Our definition of the syndrome is unclear, the etiology is obscure, the relevance of the only objective finding we have (leukocytosis) is unknown, symptoms are highly variable, the natural history of the disease has not been adequately studied and the clinical treatment trials are poorly designed, small and inconclusive. Objectives: To collaboratively develop validated NIH assessment instruments for the study of Category III prostatitis, analyze objective microscopic, microbiological, immunological and molecular biological parameters and develop a long term collaborative multicenter study in which a number of potential standardized treatment protocols could be tested. Research Design: Part 1: Retest, revalidate and revise as necessary the Principal Investigator's published prostatitis specific Symptom Frequency Questionnaire (SFQ) and Symptom Severity Index (SSI) in 100 prostatitis patients presently being studied and 100 age matched control patients. These modified indices would be subsequently used as the basis for a consensus and evidence based NIH prostatitis specific symptom assessment instrument to be tested prospectively in 200 prostatitis and 100 control patients. Part 2: Analyze objective microscopic, microbiological, immunological and molecular biological aspects of expressed prostatic secretions, semen and urine specimen after prostatic massage in these 300 patients. of potential standardized treatment protocols (conservative, antibiotic, alpha blockade and repetitive prostatic massage; alone or in combination) will be tested in patients enrolled in part l and part 2. Results from this 3 part study will be analyzed and correlated between groups and within groups, both concurrently and sequentially.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK053746-04
Application #
6329423
Study Section
Special Emphasis Panel (ZDK1-GRB-B (O2))
Program Officer
Kusek, John W
Project Start
1998-03-27
Project End
2002-11-30
Budget Start
2000-12-01
Budget End
2001-11-30
Support Year
4
Fiscal Year
2001
Total Cost
$164,100
Indirect Cost
Name
Queen's University at Kingston
Department
Type
DUNS #
City
Kingston
State
ON
Country
Canada
Zip Code
K7 3-N6
Nickel, J Curtis; Tripp, Dean A; Chuai, Shannon et al. (2008) Psychosocial variables affect the quality of life of men diagnosed with chronic prostatitis/chronic pelvic pain syndrome. BJU Int 101:59-64
Propert, K J; Litwin, M S; Wang, Y et al. (2006) Responsiveness of the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). Qual Life Res 15:299-305
Tripp, Dean A; Nickel, J Curtis; Wang, Yanlin et al. (2006) Catastrophizing and pain-contingent rest predict patient adjustment in men with chronic prostatitis/chronic pelvic pain syndrome. J Pain 7:697-708
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Nickel, J Curtis; Shoskes, Daniel; Wang, Yanlin et al. (2006) How does the pre-massage and post-massage 2-glass test compare to the Meares-Stamey 4-glass test in men with chronic prostatitis/chronic pelvic pain syndrome? J Urol 176:119-24
Nadler, Robert B; Collins, Mary McNaughton; Propert, Kathleen J et al. (2006) Prostate-specific antigen test in diagnostic evaluation of chronic prostatitis/chronic pelvic pain syndrome. Urology 67:337-42
Pontari, Michel A; McNaughton-Collins, Mary; O'leary, Michael P et al. (2005) A case-control study of risk factors in men with chronic pelvic pain syndrome. BJU Int 96:559-65
Alexander, Richard B; Propert, Kathleen J; Schaeffer, Anthony J et al. (2004) Ciprofloxacin or tamsulosin in men with chronic prostatitis/chronic pelvic pain syndrome: a randomized, double-blind trial. Ann Intern Med 141:581-9
Tripp, Dean A; Curtis Nickel, J; Landis, J Richard et al. (2004) Predictors of quality of life and pain in chronic prostatitis/chronic pelvic pain syndrome: findings from the National Institutes of Health Chronic Prostatitis Cohort Study. BJU Int 94:1279-82
Nickel, J Curtis; Alexander, Richard B; Schaeffer, Anthony J et al. (2003) Leukocytes and bacteria in men with chronic prostatitis/chronic pelvic pain syndrome compared to asymptomatic controls. J Urol 170:818-22

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