? Diabetes and diabetic kidney disease are occuring in epidemic proportions, both in the United States and worldwide. There is strong evidence that diabetic kidney disease runs in families and may have an inherited component. Therefore, the Family Investigation in Nephropathy and Diabetes (FIND) Study was developed to identify diabetic kidney failure genes. The FIND is a large multi-center study that is targeted with identifying families containing multiple diabetic members, at least one of whom also has advanced diabetic kidney disease. It will attempt to find regions that may contain the genes for diabetes and diabetic kidney failure in Europen American (Caucasian), African American, Hispanic American and Native American families. To date, more than 1,400 different families have been enrolled. The study was started in September 1999 and is being conducted at 8 participating investigative centers around the country and at a single genetic analysis and data coordinating center. After the families are identified and provide blood and urine samples, genetic material (DNA) is being evaluated in an attempt to identify genes that predispose to diabetic kidney failure and diabetic eye disease. During the next two years, the Wake Forest University School of Medicine site will attempt to evaluate approximately 250 diabetic subjects who previously participated in the FIND study for the presence of diabetic eye disease. These individuals will be recontacted and asked to provide medical records from their eye doctors or have pictures taken of the blood vessels in back of their eyes by an opthamologist. We will also complete the evaluation of the genetic data in all FIND families; and we will be preparing publications that reveal the results of the genetic analyses for diabetic kidney disease and diabetic eye disease. The identification of genes that cause diabetic complications will take us one step closer to finding treatments that may have the potential to slow or prevent the development of these serious complications of diabetes mellitus ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
2U01DK057298-06
Application #
7037227
Study Section
Special Emphasis Panel (ZDK1-GRB-3 (O1))
Program Officer
Rasooly, Rebekah S
Project Start
1999-09-30
Project End
2007-08-31
Budget Start
2005-09-30
Budget End
2006-08-31
Support Year
6
Fiscal Year
2005
Total Cost
$75,000
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Williams, Robert C; Elston, Robert C; Kumar, Pankaj et al. (2016) Selecting SNPs informative for African, American Indian and European Ancestry: application to the Family Investigation of Nephropathy and Diabetes (FIND). BMC Genomics 17:325
Iyengar, Sudha K; Sedor, John R; Freedman, Barry I et al. (2015) Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND). PLoS Genet 11:e1005352
Ng, Maggie C Y; Shriner, Daniel; Chen, Brian H et al. (2014) Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes. PLoS Genet 10:e1004517
Sandholm, Niina; McKnight, Amy Jayne; Salem, Rany M et al. (2013) Chromosome 2q31.1 associates with ESRD in women with type 1 diabetes. J Am Soc Nephrol 24:1537-43
Bostrom, Meredith A; Kao, W H Linda; Li, Man et al. (2012) Genetic association and gene-gene interaction analyses in African American dialysis patients with nondiabetic nephropathy. Am J Kidney Dis 59:210-21
Igo Jr, Robert P; Iyengar, Sudha K; Nicholas, Susanne B et al. (2011) Genomewide linkage scan for diabetic renal failure and albuminuria: the FIND study. Am J Nephrol 33:381-9
Sedor, John R; Freedman, Barry I (2010) Genetics and the kidney: promise, potential, and challenges. Introduction. Semin Nephrol 30:99-100
Freedman, Barry I; Parekh, Rulan S; Kao, W H Linda (2010) Genetic basis of nondiabetic end-stage renal disease. Semin Nephrol 30:101-10
Freedman, Barry I; Murea, Mariana (2010) Potential effects of MYH9-associated nephropathy on dialysis and kidney transplant outcomes. Semin Dial 23:244-7
Bleyer, Anthony J; Sedor, John R; Freedman, Barry I et al. (2008) Risk factors for development and progression of diabetic kidney disease and treatment patterns among diabetic siblings of patients with diabetic kidney disease. Am J Kidney Dis 51:29-37

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