This proposal responds to RFA-DK-18-510, which requests applications for Research Sites to continue in the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN). In this application, the University of Washington (UW) seeks support for a Research Site to participate in efforts to unravel the clinically confounding symptoms of the lower urinary tract. This proposal was developed following the guidelines stipulated by the National Institute of Diabetes, Digestive and Kidney diseases (NIDDK).
The aim of the proposed UW Research Site, in conjunction with the Data Coordination Center and LURN Research Sites, is to develop and validate symptom-based instruments to measure lower urinary tract symptoms both in men and women, and to better define the subtypes of persons with lower urinary tract symptoms. The key responsibilities of the Research Site will be to adopt the study protocols developed by the LURN investigators, validate the developed Patient Reported Outcome (PRO) measures, recruit study participants, and conduct extensive characterization (subtyping) of them.

Public Health Relevance

The aim of the proposed UW Research Site, in conjunction with the Data Coordination Center and existing LURN Research Sites, is to develop and validate urinary symptom-based instruments both in men and women, and to better define the subtypes of men and women with lower urinary tract symptoms. The relevance of the project is to identify subgroups of persons with urinary symptoms, in order to find the causes of the symptoms and identify better treatments.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK100011-07
Application #
10011799
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Mullins, Christopher V
Project Start
2013-07-15
Project End
2024-08-31
Budget Start
2020-09-01
Budget End
2021-08-31
Support Year
7
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Washington
Department
Urology
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
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Cameron, Anne P; Smith, Abigail R; Lai, H Henry et al. (2018) Bowel function, sexual function, and symptoms of pelvic organ prolapse in women with and without urinary incontinence. Neurourol Urodyn 37:2586-2596
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Cameron, Anne P; Lewicky-Gaupp, Christina; Smith, Abigail R et al. (2018) Baseline Lower Urinary Tract Symptoms in Patients Enrolled in LURN: A Prospective, Observational Cohort Study. J Urol 199:1023-1031
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Lai, H Henry; Naliboff, Bruce; Liu, Alice B et al. (2018) The LURN Research Network Neuroimaging and Sensory Testing (NIST) Study: Design, protocols, and operations. Contemp Clin Trials 74:76-87
Bradley, Catherine S; Erickson, Bradley A; Messersmith, Emily E et al. (2017) Evidence of the Impact of Diet, Fluid Intake, Caffeine, Alcohol and Tobacco on Lower Urinary Tract Symptoms: A Systematic Review. J Urol 198:1010-1020
Yang, Claire C; Weinfurt, Kevin P; Merion, Robert M et al. (2016) Symptoms of Lower Urinary Tract Dysfunction Research Network. J Urol 196:146-52