. Consortium for the Study of Pancreatitis: Pittsburgh Clinical Center. The Consortium for the Study of Pancreatitis: Pittsburgh Clinical Center (PCC) is a multidisciplinary clinical- translational program at the University of Pittsburgh and UPMC. The PCC is one of the 10 founding members of the Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CPDPC). The organizational structure of PCC allows comprehensive epidemiological, clinical and biological characterization of patients with pancreatic disorders in order to conduct clinical, translational and mechanistic studies of recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) and their sequelae such as Type 3c diabetes and pancreatic cancer. The PCC is highly integrated at all levels of the CPDPC, including leadership, participation in Committees and Working Groups, contribution to primary cohorts, several ancillary studies and publications. PCC has been effective in utilizing the CPDPC infrastructure and resources for high-quality scientific projects. In the next five years of funding, the PCC is committed to completing ascertainment of the primary CPDPC cohorts, execution of the currently approved ancillary studies, and participating in new projects. We will also propose concepts for three new ancillary studies that will utilize the infrastructure and resources of the CPDPC.
Our specific aims are:
Aim 1. Contribute to completing the acquisition of CPDPC?s primary cohorts and ongoing ancillary studies.
Aim 2. We will propose and support new ancillary projects to use the infrastructure created with the primary cohorts and ongoing ancillary studies. As part of Aim 2, we propose concepts for three ancillary projects, to ? i) Develop a Chronic Pancreatitis Risk Score (CPRS) for use in randomized clinical trials of CP, ii) Identify Urine Biomarkers of Pain (UBP) for mechanism-based phenotyping of CP pain, and iii) Use a genotying approach to enrich the New Onset Diabetes (NOD) cohort. Our existing and well-established, efficient and effective clinical and research infrastructure for patient accrual, sample processing, data management and transfer, and analysis will support the program. The rich clinical volume, diverse investigator expertise in all critical areas such as pancreatology, epidemiology, early detection of cancer, genetics, physiology, imaging, endocrinology, biostatistics and bioinformatics, and all relevant disease subtypes, administrative authority in clinical and research areas ensure continued success. Our track record of leadership, strong collaborations and working relationships within the CPDPC and other collaborative networks will also ensure continued success and effectiveness of the CPDPC.

Public Health Relevance

. The Consortium for the Study of Pancreatitis: Pittsburgh Clinical Center (PCC) is a clinical-translational program at the University of Pittsburgh and UPMC designed to conduct studies related to chronic pancreatitis, diabetes and pancreatic cancer. As a member of the Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CPDPC), the PCC will participate in collaborative studies planned by the consortium. The track record of accomplishments of the PCC in the CPDPC as well as leadership and contributions to other collaborative networks will ensure continued success and effectiveness of the CPDPC.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
2U01DK108306-06
Application #
10072430
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Unalp-Arida, Aynur
Project Start
2015-09-28
Project End
2025-06-30
Budget Start
2020-09-03
Budget End
2021-06-30
Support Year
6
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15260
Fisher, William E; Cruz-Monserrate, Zobeida; McElhany, Amy L et al. (2018) Standard Operating Procedures for Biospecimen Collection, Processing, and Storage: From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer. Pancreas 47:1213-1221
Yadav, Dhiraj; Slivka, Adam (2018) Managing chronic pancreatitis: the view from medical pancreatology. Am J Gastroenterol 113:1108-1110
Phillips, Anna Evans; Shah, Nilesh; Borhani, Amir A et al. (2018) Prior History of Pancreatitis Accelerates the Development of Pancreatic Adenocarcinoma. Pancreas 47:1262-1266
Coté, Gregory A; Yadav, Dhiraj; Abberbock, Judah A et al. (2018) Recurrent Acute Pancreatitis Significantly Reduces Quality of Life Even in the Absence of Overt Chronic Pancreatitis. Am J Gastroenterol 113:906-912
Zhan, Wei; Shelton, Celeste A; Greer, Phil J et al. (2018) Germline Variants and Risk for Pancreatic Cancer: A Systematic Review and Emerging Concepts. Pancreas 47:924-936
Hart, Phil A; Andersen, Dana K; Mather, Kieren J et al. (2018) Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis: Rationale and Methodology for the DETECT Study From the Consortium for the Study of Chronic Pancreatitis Pancreas 47:1239-1243
Machicado, Jorge D; Chari, Suresh T; Timmons, Lawrence et al. (2018) A population-based evaluation of the natural history of chronic pancreatitis. Pancreatology 18:39-45
Serrano, Jose; Andersen, Dana K; Forsmark, Christopher E et al. (2018) Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer: From Concept to Reality. Pancreas 47:1208-1212
Forsmark, Christopher E; Andersen, Dana K; Farrar, John T et al. (2018) Accelerating the Drug Delivery Pipeline for Acute and Chronic Pancreatitis: Summary of the Working Group on Drug Development and Trials in Chronic Pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Pancreas 47:1200-1207
Setiawan, Veronica Wendy; Monroe, Kristine; Lugea, Aurelia et al. (2017) Uniting Epidemiology and Experimental Disease Models for Alcohol-Related Pancreatic Disease. Alcohol Res 38:173-182

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