The mechanistic underpinnings of diseases involving the exocrine pancreas are poorly understood. Chronic pancreatitis is often accompanied by inflammation of the pancreas, irreversible fibrosis, and destruction of the pancreatic parenchyma resulting in abdominal pain, malnutrition, exocrine pancreatic insufficiency, pancreatogenic diabetes, and, in some cases, pancreas cancer. We have developed a network of adult and pediatric investigators to form The Ohio State University Clinical Center (OSU CC). In a multidisciplinary collaboration with other clinical centers in the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer Clinical Centers (CPDPC-CCs) (U01), the OSU CC has helped develop four (4) major observational studies during the initial funding cycle to address research gaps in our understanding of diseases of the exocrine pancreas. Specifically, the OSU CC seeks to validate proposed diagnostic biomarkers in chronic pancreatitis, pancreatogenic diabetes, and pancreas cancer.

Public Health Relevance

We have developed a network of adult and pediatric medical research institutions to form The Ohio State University Clinical Center (OSU CC). In a multidisciplinary collaboration with other clinical centers in the Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer Clinical Centers (CSCPDPC- CCs) (U01), the OSU CC has helped developed 4 major observational studies during the initial funding cycle that address research gaps in our understanding of the exocrine pancreas. Specifically, the OSU CC seeks to confirm and validate proposed diagnostic biomarkers in chronic pancreatitis, pancreaticogenic diabetes and pancreas cancer.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01DK108327-06S1
Application #
10263457
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Unalp-Arida, Aynur
Project Start
2015-09-28
Project End
2025-06-30
Budget Start
2020-09-08
Budget End
2021-06-30
Support Year
6
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Ohio State University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Eibl, Guido; Cruz-Monserrate, Zobeida; Korc, Murray et al. (2018) Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer. J Acad Nutr Diet 118:555-567
Serrano, Jose; Andersen, Dana K; Forsmark, Christopher E et al. (2018) Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer: From Concept to Reality. Pancreas 47:1208-1212
Phillips, Anna Evans; LaRusch, Jessica; Greer, Phil et al. (2018) Known genetic susceptibility factors for chronic pancreatitis in patients of European ancestry are rare in patients of African ancestry. Pancreatology :
Krishna, Somashekar G; Kruger, Andrew J; Patel, Nishi et al. (2018) Cholecystectomy During Index Admission for Acute Biliary Pancreatitis Lowers 30-Day Readmission Rates. Pancreas 47:996-1002
Fisher, William E; Cruz-Monserrate, Zobeida; McElhany, Amy L et al. (2018) Standard Operating Procedures for Biospecimen Collection, Processing, and Storage: From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer. Pancreas 47:1213-1221
Coté, Gregory A; Yadav, Dhiraj; Abberbock, Judah A et al. (2018) Recurrent Acute Pancreatitis Significantly Reduces Quality of Life Even in the Absence of Overt Chronic Pancreatitis. Am J Gastroenterol 113:906-912
Abu-El-Haija, Maisam; El-Dika, Samer; Hinton, Alice et al. (2018) Acute Pancreatitis Admission Trends: A National Estimate through the Kids' Inpatient Database. J Pediatr 194:147-151.e1
Uc, Aliye; Perito, Emily R; Pohl, John F et al. (2018) INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE Cohort Study: Design and Rationale for INSPPIRE 2 From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer. Pancreas 47:1222-1228
Hart, Phil A; Andersen, Dana K; Mather, Kieren J et al. (2018) Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis: Rationale and Methodology for the DETECT Study From the Consortium for the Study of Chronic Pancreatitis Pancreas 47:1239-1243
Bennike, Tue Bjerg; Bellin, Melena D; Xuan, Yue et al. (2018) A Cost-Effective High-Throughput Plasma and Serum Proteomics Workflow Enables Mapping of the Molecular Impact of Total Pancreatectomy with Islet Autotransplantation. J Proteome Res 17:1983-1992

Showing the most recent 10 out of 34 publications