This proposal from the California Center builds upon a five year research project, SEARCH for Diabetes in Youth, its standardized data collection effort, experienced investigator team, established case ascertainment infrastructure, and ethnically diverse population base. This is a common, integrated application from the six SEARCH clinical centers, which proposes to continue and expand the work performed by SEARCH in order to address the following specific research aims:
AIM 1 : Prospectively ascertain newly diagnosed (2006- 2009) incident cases age less than 20 years in order to estimate temporal trends in incidence of diabetes mellitus in youth;
AIM 2 : Conduct longitudinal follow-up of incident cases already recruited to SEARCH in 2002-2005 in order to document the evolution of newly diagnosed diabetes according to clinical and biochemical factors;
AIM 3 : Complete analyses initiated in the first five years of SEARCH and expand the scope of quality of care assessment to encompass more broadly defined concepts and measures of quality;
AIM 4 : Develop and validate simple and low-cost case definitions and classifications of diabetes types in youth that can be used for public health surveillance. The novelty of this proposal includes its comprehensive nature that brings together major and timely facets of childhood diabetes research: an epidemiologic study, unique in the United States, of temporal trends in the incidence of diabetes in youth; a pathophysiologic component addressing the natural history of diabetes in youth; a study of processes of care and quality of life; and a public health perspective on case classification of diabetes in youth. The strengths of the California Center are its large, diverse population; that most youth with diabetes receive health care from 1 of the 8 pediatric endocrinologists in the region; and the availability of a vast amount of electronic health data. Of the more than 770,000 youth less than 20 years, over half are Hispanic, African American, or Asian/Pacific Islander,which is representative of southern California. This research is critically important to public health. It will provide information about whether and how much diabetes incidence in the United States is increasing among youth of different backgrounds and how diabetes affects physical health, including complications, as well as data on the quality of care and the quality of life of youth with diabetes.

Agency
National Institute of Health (NIH)
Institute
National Center for Chronic Disease Prev and Health Promo (NCCDPHP)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01DP000246-04S1
Application #
7685927
Study Section
Special Emphasis Panel (ZDP1-FXR (DT))
Program Officer
Sims, Joyner
Project Start
2005-09-30
Project End
2010-09-29
Budget Start
2008-09-30
Budget End
2009-09-29
Support Year
4
Fiscal Year
2008
Total Cost
$109,079
Indirect Cost
Name
Kaiser Foundation Research Institute
Department
Type
DUNS #
150829349
City
Oakland
State
CA
Country
United States
Zip Code
94612
Li, Chao; D'Agostino Jr, Ralph B; Dabelea, Dana et al. (2018) Longitudinal association between eating frequency and hemoglobin A1c and serum lipids in diabetes in the SEARCH for Diabetes in Youth study. Pediatr Diabetes :
Kahkoska, Anna R; Isom, Scott; Divers, Jasmin et al. (2018) The early natural history of albuminuria in young adults with youth-onset type 1 and type 2 diabetes. J Diabetes Complications 32:1160-1168
Costacou, Tina; Crandell, Jamie; Kahkoska, Anna R et al. (2018) Dietary Patterns Over Time and Microalbuminuria in Youth and Young Adults With Type 1 Diabetes: The SEARCH Nutrition Ancillary Study. Diabetes Care 41:1615-1622
Jaiswal, Mamta; Divers, Jasmin; Urbina, Elaine M et al. (2018) Cardiovascular autonomic neuropathy in adolescents and young adults with type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth Cohort Study. Pediatr Diabetes 19:680-689
Reynolds, Kristi; Saydah, Sharon H; Isom, Scott et al. (2018) Mortality in youth-onset type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth study. J Diabetes Complications 32:545-549
Liese, Angela D; Ma, Xiaonan; Ma, Xiaoguang et al. (2018) Dietary quality and markers of inflammation: No association in youth with type 1 diabetes. J Diabetes Complications 32:179-184
Kahkoska, Anna R; Shay, Christina M; Couch, Sarah C et al. (2018) Sociodemographic associations of longitudinal adiposity in youth with type 1 diabetes. Pediatr Diabetes 19:1429-1440
Mendoza, Jason A; Haaland, Wren; D'Agostino, Ralph B et al. (2018) Food insecurity is associated with high risk glycemic control and higher health care utilization among youth and young adults with type 1 diabetes. Diabetes Res Clin Pract 138:128-137
Kahkoska, Anna R; Shay, Christina M; Crandell, Jamie et al. (2018) Association of Race and Ethnicity With Glycemic Control and Hemoglobin A1c Levels in Youth With Type 1 Diabetes. JAMA Netw Open 1:
Pinto, Cathy A; Stafford, Jeanette M; Wang, Tongtong et al. (2018) Changes in diabetes medication regimens and glycemic control in adolescents and young adults with youth-onset type 2 diabetes: The SEARCH for diabetes in youth study. Pediatr Diabetes :

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