The Macular Photocoagulation Study is a multi-center collaborative trial of the photocoagulation of subretinal neovascular membranes in senile macular degeneration and presumed ocular histoplasmosis. The objectives in presumed ocular histoplasmosis are: A) To determine by means of a randomized controlled clinical trial whether Argon laser photocoagulation is a benefit in preventing visual acuity loss in eyes with presumed ocular histoplasmosis and a neovascular membrane 200 to 1,500 microns from the center of the fovea. B) To document the natural history of choroidal neovascular membranes in the macula in the fellow eye in presumed ocular histoplasmosis syndrome with particular reference to subfoveal neovascular membranes to determine the feasibility of commencing and randomizing clinical trials for this latter group of eyes. C) To define precisely the risk of development of symptomatic choroidal neovascular membranes from an atrophic scar (Histo spots) in the macula of the fellow eye. The objectives in senile macular degeneration are: A) To evaluate by means of a randomized clinical trial, the role of Argon laser photocoagulation in the management of choroidal neovascular membranes between 200 and 1,500 microns from the fovea. B) To determine the natural history of subfoveal neovascular membranes in the fellow eye of patients with senile maculopathy with a view to considering a randomized clinical trial of photocoagulation for subfoveal neovascular membranes. C) To describe precisely and quantitatively the natural history of drusen in Bruch's membrane with partial reference to the risk of developing serious detachments of the retinal pigment epithelium (Avascular disciform) in eyes with senile macular degeneration, to consider a randomized trial for such eyes.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01EY002548-07
Application #
3551219
Study Section
Vision Research and Training Committee (VSN)
Project Start
1979-01-01
Project End
1986-12-31
Budget Start
1985-01-01
Budget End
1985-12-31
Support Year
7
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Medical College of Wisconsin
Department
Type
Schools of Medicine
DUNS #
073134603
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Jefferys, Joan L; Alexander, Judith; Hiner, Cheryl J et al. (2008) Reproducibility of gradings of retinal photographs in eyes with subfoveal choroidal neovascularization and age-related macular degeneration in the macular photocoagulation study. Ophthalmic Epidemiol 15:191-201
(1997) Risk factors for choroidal neovascularization in the second eye of patients with juxtafoveal or subfoveal choroidal neovascularization secondary to age-related macular degeneration. Macular Photocoagulation Study Group. Arch Ophthalmol 115:741-7
(1996) Five-year follow-up of fellow eyes of individuals with ocular histoplasmosis and unilateral extrafoveal or juxtafoveal choroidal neovascularization. Macular Photocoagulation Study Group. Arch Ophthalmol 114:677-88
(1996) Occult choroidal neovascularization. Influence on visual outcome in patients with age-related macular degeneration. Macular Photocoagulation Study Group. Arch Ophthalmol 114:400-12
(1995) The influence of treatment extent on the visual acuity of eyes treated with Krypton laser for juxtafoveal choroidal neovascularization. Macular Photocoagulation Study Group. Arch Ophthalmol 113:190-4
(1995) Laser photocoagulation for neovascular lesions nasal to the fovea. Results from clinical trials for lesions secondary to ocular histoplasmosis or idiopathic causes. Macular Photocoagulation Study Group. Arch Ophthalmol 113:56-61
(1994) Visual outcome after laser photocoagulation for subfoveal choroidal neovascularization secondary to age-related macular degeneration. The influence of initial lesion size and initial visual acuity. Macular Photocoagulation Study Group. Arch Ophthalmol 112:480-8
(1994) Laser photocoagulation for juxtafoveal choroidal neovascularization. Five-year results from randomized clinical trials. Macular Photocoagulation Study Group. Arch Ophthalmol 112:500-9
(1994) Persistent and recurrent neovascularization after laser photocoagulation for subfoveal choroidal neovascularization of age-related macular degeneration. Macular Photocoagulation Study Group. Arch Ophthalmol 112:489-99
(1994) Evaluation of argon green vs krypton red laser for photocoagulation of subfoveal choroidal neovascularization in the macular photocoagulation study. Macular Photocoagulation Study (MPS) Group. Arch Ophthalmol 112:1176-84

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