Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01EY006855-05S2
Application #
3551961
Study Section
Vision Research and Training Committee (VSN)
Project Start
1986-09-30
Project End
1992-03-31
Budget Start
1990-09-30
Budget End
1992-03-31
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Veterinary Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Gardiner, Kristin L; Downs, Louise; Berta-Antalics, Agnes I et al. (2016) Photoreceptor proliferation and dysregulation of cell cycle genes in early onset inherited retinal degenerations. BMC Genomics 17:221
Marsili, Stefania; Genini, Sem; Sudharsan, Raghavi et al. (2015) Exclusion of the unfolded protein response in light-induced retinal degeneration in the canine T4R RHO model of autosomal dominant retinitis pigmentosa. PLoS One 10:e0115723
Genini, Sem; Beltran, William A; Aguirre, Gustavo D (2013) Up-regulation of tumor necrosis factor superfamily genes in early phases of photoreceptor degeneration. PLoS One 8:e85408
Komáromy, András M; Rowlan, Jessica S; Corr, Amanda T Parton et al. (2013) Transient photoreceptor deconstruction by CNTF enhances rAAV-mediated cone functional rescue in late stage CNGB3-achromatopsia. Mol Ther 21:1131-41
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Guziewicz, Karina E; Zangerl, Barbara; Komáromy, András M et al. (2013) Recombinant AAV-mediated BEST1 transfer to the retinal pigment epithelium: analysis of serotype-dependent retinal effects. PLoS One 8:e75666
Beltran, William A; Cideciyan, Artur V; Lewin, Alfred S et al. (2012) Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa. Proc Natl Acad Sci U S A 109:2132-7
Guziewicz, Karina E; Aguirre, Gustavo D; Zangerl, Barbara (2012) Modeling the structural consequences of BEST1 missense mutations. Adv Exp Med Biol 723:611-8
Kukekova, Anna V; Johnson, Jennifer L; Teiling, Clotilde et al. (2011) Sequence comparison of prefrontal cortical brain transcriptome from a tame and an aggressive silver fox (Vulpes vulpes). BMC Genomics 12:482
Guziewicz, Karina E; Slavik, Julianna; Lindauer, Sarah J P et al. (2011) Molecular consequences of BEST1 gene mutations in canine multifocal retinopathy predict functional implications for human bestrophinopathies. Invest Ophthalmol Vis Sci 52:4497-505

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