Research Triangle Institute (RTI) proposes to continue serving as the Data Coordinating Center (DCC) for the Cooperative Multicenter Neonatal Research Network (NRN). The senior staff proposed for this continued effort are the same as those who have directed the DCC for the last 4 years. In addition, they have directed other data coordinating centers for 30 years and have completed or are now conducting seven major studies in maternal/perinatal/neonatal research. Current studies are three networks, including the currently proposed one, that conduct multisite, multiprotocol studies in neonatology and maternal and child health. Dr. W. Kenneth Poole, the proposed Principal Investigator (PI), has been the PI or Co-PI of 12 major DCC projects. In particular, he is the current PI of the DCC for the NRN, is a protocol statistician for the Global Network for Women's and Children's Health Research, has been the PI of the High Frequency Ventilation (HIFI) and Respiratory Distress Syndrome (RDS) studies, was Co-PI of the Vaginal Infection & Prematurity (VIP) study, and was senior statistician on NICHD's Study of Early Child Care (SECC) and DC Initiative studies. Also, Dr. Poole and some of our proposed staff worked with four of the current Network PIs on the HIFI and RDS studies prior to taking over the DCC for the NRN. All of our proposed staff have worked together for many years on DCC projects including the studies in maternal/perinatal/neonatal research. RTI has Rockville, MD offices next door to NICHD. A coordinator, a senior analyst, three statisticians (including the Co-PI), and a support person are located in this Rockville facility. RTI assumes a leadership role for the Network in the areas of statistical design and analysis, data collection procedures, data management and processing, quality control, randomization, study logistics, Network communications, and tracking drug supplies and specimens. We use state-of-the-art methods of data collection, processing, and management, including computer-assisted data collection methods, electronic data transfer, a web site, and Internet linkages with the study collaborators. RTI's matrix management structure, whereby individual staff may be assigned to several projects, provides considerable flexibility in allocating additional resources to projects at times of peak needs. Institute staff have an impressive track record working with site PIs and statisticians in the development of manuscripts for publication.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HD036790-10
Application #
7247248
Study Section
Special Emphasis Panel (ZHD1-DSR-H (05))
Program Officer
Higgins, Rosemary
Project Start
1998-08-01
Project End
2008-05-31
Budget Start
2007-06-01
Budget End
2008-05-31
Support Year
10
Fiscal Year
2007
Total Cost
$3,106,224
Indirect Cost
Name
Research Triangle Institute
Department
Type
DUNS #
004868105
City
Research Triangle
State
NC
Country
United States
Zip Code
27709
Brumbaugh, Jane E; Colaizy, Tarah T; Saha, Shampa et al. (2018) Oral feeding practices and discharge timing for moderately preterm infants. Early Hum Dev 120:46-52
Jilling, Tamas; Ambalavanan, Namasivayam; Cotten, C Michael et al. (2018) Surgical necrotizing enterocolitis in extremely premature neonates is associated with genetic variations in an intergenic region of chromosome 8. Pediatr Res 83:943-953
Srinivasan, Lakshmi; Page, Grier; Kirpalani, Haresh et al. (2017) Genome-wide association study of sepsis in extremely premature infants. Arch Dis Child Fetal Neonatal Ed 102:F439-F445
Watterberg, K L; Fernandez, E; Walsh, M C et al. (2017) Barriers to enrollment in a randomized controlled trial of hydrocortisone for cardiovascular insufficiency in term and late preterm newborn infants. J Perinatol 37:1220-1223
Denson, Lee A; McDonald, Scott A; Das, Abhik et al. (2017) Early Elevation in Interleukin-6 is Associated with Reduced Growth in Extremely Low Birth Weight Infants. Am J Perinatol 34:240-247
Younge, Noelle; Goldstein, Ricki F; Bann, Carla M et al. (2017) Survival and Neurodevelopmental Outcomes among Periviable Infants. N Engl J Med 376:617-628
D'Angio, Carl T; Ambalavanan, Namasivayam; Carlo, Waldemar A et al. (2016) Blood Cytokine Profiles Associated with Distinct Patterns of Bronchopulmonary Dysplasia among Extremely Low Birth Weight Infants. J Pediatr 174:45-51.e5
Weissman, Scott J; Hansen, Nellie I; Zaterka-Baxter, Kristen et al. (2016) Emergence of Antibiotic Resistance-Associated Clones Among Escherichia coli Recovered From Newborns With Early-Onset Sepsis and Meningitis in the United States, 2008-2009. J Pediatric Infect Dis Soc 5:269-76
Rysavy, Matthew A; Li, Lei; Bell, Edward F et al. (2015) Between-hospital variation in treatment and outcomes in extremely preterm infants. N Engl J Med 372:1801-11
Ambalavanan, Namasivayam; Cotten, C Michael; Page, Grier P et al. (2015) Integrated genomic analyses in bronchopulmonary dysplasia. J Pediatr 166:531-7.e13

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