The University of South Florida (USF) Department of Pediatrics is the soleprovider of comprehensive care to HIV-infected children and adolescents in ten counties throughout central and southwest Florida. Cumulative HIV Surveillance Data shows that 434 youth have been identified as HIV- infected in our catchment area; 249 of these have been identified in the past two years. The university and its network of community providers have embraced efforts to expand outreach and education to adolescents and have researched ways to effectively communicate with its population. The USF Adolescent HIV Program plan to contribute this local expertise to the national adolescent scientific agenda and provide youth with maximal opportunity for state of the art care. To accomplish this goal, the following objectives will be met. Develop an Adolescent Medicine Trial Unit (AMTU) at USF in Tampa utilizing existing infrastructure. This infrastructure includes the Adolescence HIV Program that provides primary and specialty care services, Adult HIV Program providing care at USF and the Hillsborough County Health Department, and the Florida Family AIDS Network, a Title IV Program USF has established partnerships in the community with agencies that provide HIV case management, outreach testing and education services. These partners will ensure an ability to provide comprehensive education services to adolescents and to assist in the recruitment of high-risk youth for our studies. Recruit and enroll 75 HIV infected youth from the existing clinic population and from expanded efforts to identify and ensure youth are referred to the clinic for care. Recruit 125 HIV-youth who are at high risk by utilizing existing source most importantly our University Clinic, Health Department family planning, STD, pediatrics and maternal health clinics, the Regional Early Intervention Consultant (EIC), and community AIDS service organizations. Collaborate with the Adolescent Medicine Trial Group to develop and evaluate innovative programs to reach youth and share and evaluate the innovations this community has developed to educate youth about HIV. Enroll HIV infected adolescents in treatment trials and evaluate the barriers to enrollment and retention. This would include not only new therapies, but also new approaches such as once daily and direct observed therapy protocols. The inclusion of USF Adolescent HIV Program as an AMTU will further the efforts to identify, prevent and treat HIV in this area of the country where minority and youth infection is rising at alarming rates.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HD040497-03
Application #
6637412
Study Section
Special Emphasis Panel (ZHD1-DRG-D (02))
Program Officer
Nugent, Robert
Project Start
2001-04-15
Project End
2006-02-28
Budget Start
2003-03-01
Budget End
2004-02-29
Support Year
3
Fiscal Year
2003
Total Cost
$771,303
Indirect Cost
Name
University of South Florida
Department
Pediatrics
Type
Schools of Medicine
DUNS #
069687242
City
Tampa
State
FL
Country
United States
Zip Code
33612
Harper, Gary W; Tyler, April Timmons; Bruce, Douglas et al. (2016) Drugs, Sex, and Condoms: Identification and Interpretation of Race-Specific Cultural Messages Influencing Black Gay and Bisexual Young Men Living with HIV. Am J Community Psychol 58:463-476
Rudy, Bret J; Kapogiannis, Bill G; Worrell, Carol et al. (2015) Immune Reconstitution but Persistent Activation After 48 Weeks of Antiretroviral Therapy in Youth With Pre-Therapy CD4 >350 in ATN 061. J Acquir Immune Defic Syndr 69:52-60
Havens, Peter L; Hazra, Rohan; Stephensen, Charles B et al. (2014) Vitamin D3 supplementation increases fibroblast growth factor-23 in HIV-infected youths treated with tenofovir disoproxil fumarate. Antivir Ther 19:613-8
Harper, Gary W; Bruce, Douglas; Hosek, Sybil G et al. (2014) Resilience processes demonstrated by young gay and bisexual men living with HIV: implications for intervention. AIDS Patient Care STDS 28:666-76
Porter, Travis R; Li, Xuelin; Stephensen, Charles B et al. (2013) Genetic associations with 25-hydroxyvitamin D deficiency in HIV-1-infected youth: fine-mapping for the GC/DBP gene that encodes the vitamin D-binding protein. Front Genet 4:234
Harper, Gary W; Fernandez, Isabel M; Bruce, Douglas et al. (2013) The role of multiple identities in adherence to medical appointments among gay/bisexual male adolescents living with HIV. AIDS Behav 17:213-23
Havens, Peter L; Kiser, Jennifer J; Stephensen, Charles B et al. (2013) Association of higher plasma vitamin D binding protein and lower free calcitriol levels with tenofovir disoproxil fumarate use and plasma and intracellular tenofovir pharmacokinetics: cause of a functional vitamin D deficiency? Antimicrob Agents Chemother 57:5619-28
Lee, Sonia; Kapogiannis, Bill G; Flynn, Patricia M et al. (2013) Comprehension of a simplified assent form in a vaccine trial for adolescents. J Med Ethics 39:410-2
Willard, Nancy; Chutuape, Kate; Stines, Stephanie et al. (2012) Bridging the gap between individual-level risk for HIV and structural determinants: using root cause analysis in strategic planning. J Prev Interv Community 40:103-17
Havens, Peter L; Stephensen, Charles B; Hazra, Rohan et al. (2012) Vitamin D3 decreases parathyroid hormone in HIV-infected youth being treated with tenofovir: a randomized, placebo-controlled trial. Clin Infect Dis 54:1013-25

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