This is a revised proposal for a Clinical Site in the """"""""Cooperative multicenter traumatic brain injury clinical trials network."""""""" The proposal aims to establish a Traumatic Brain Injury (TBI) Research Center in Dallas, Texas, to be based at Parkland Memorial Hospital (PMH), with the collaboration of the Baylor Institute for Rehabilitation (BIR). Both institutions are nationally recognized for neurosurgical, neurological, and rehabilitation care. Parkland is the major Level I Trauma Center in the North Texas area, serving a population of approximately 5 million. PMH averages approximately 350 admissions for TBI each year, and 140 of these are for moderately severe to severe brain injury. All TBI patients are evaluated by the Physical Medicine and Rehabilitation service, and appropriate rehabilitation follow-up is obtained. The great majority of patients are referred to one of two rehabilitation units, the rehabilitation unit at PMH and BIR. Both the Parkland rehabilitation unit and the TBI unit at BIR are collaborators on this project. The PI, Dr. Eugene George, is Chief of the Neurosurgical Service at PMH. He has experience in multicenter collaborative trials in TBI, subarachnoid hemorrhage, and spinal cord injury. The other collaborators in the project all have an academic and clinical commitment to the care of patients with TBI. Dr. Lisa-Ann Wuermser is director of the Physical Medicine and Rehabilitation service at PMH, and an active investigator on trials on SCI and TBI. Dr. Mary Carlile is director of the TBI Program at BIR, and is widely recognized for excellence in management of these patients. Dr. Ramon Diaz-Arrastia is a neurologist and clinical neurophysiologist who is interested in the mechanisms of brain injury. Dr. Munro Cullum is Director of Neuropsychology at UT Southwestern, and has an extensive record of successful collaborative research in TBI and other neurodegenerative diseases. The concept proposal incorporated into this submission aims to determine the efficacy and value of continuous video-EEG (CVEEG) monitoring in patients with moderately-severe to severe TBI. Recent technical advances have made this possible, and small uncontrolled studies indicate that a significant fraction of patients with TBI have subtle nonconvulsive seizures (NCS), that would not be recognized unless CVEEG is performed. The concept proposal aims to determine whether aggressive treatment of NCS results in improved functional outcome.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HD042652-03
Application #
6917252
Study Section
Special Emphasis Panel (ZHD1-RRG-K (BI))
Program Officer
Ansel, Beth
Project Start
2003-07-01
Project End
2008-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
3
Fiscal Year
2005
Total Cost
$622,637
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Neurology
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Ding, Kan; Gong, Yunhua; Modur, Pradeep N et al. (2016) Temporal lobe volume predicts Wada memory test performance in patients with mesial temporal sclerosis. Epilepsy Res 120:25-30
Abdelmalik, Peter A; Boorman, David W; Tracy, Joseph et al. (2016) Acute Traumatic Coagulopathy Accompanying Isolated Traumatic Brain Injury is Associated with Worse Long-Term Functional and Cognitive Outcomes. Neurocrit Care 24:361-70
Yue, John K; Pronger, Angela M; Ferguson, Adam R et al. (2015) Association of a common genetic variant within ANKK1 with six-month cognitive performance after traumatic brain injury. Neurogenetics 16:169-80
Gupta, Puneet K; Sayed, Nasreen; Ding, Kan et al. (2014) Subtypes of post-traumatic epilepsy: clinical, electrophysiological, and imaging features. J Neurotrauma 31:1439-43
Hudak, Anne M; Peng, Lifang; Marquez de la Plata, Carlos et al. (2014) Cytotoxic and vasogenic cerebral oedema in traumatic brain injury: assessment with FLAIR and DWI imaging. Brain Inj 28:1602-9
Arenivas, Ana; Diaz-Arrastia, Ramon; Spence, Jeffrey et al. (2014) Three approaches to investigating functional compromise to the default mode network after traumatic axonal injury. Brain Imaging Behav 8:407-19
Anglin, Catherine O; Spence, Jeffrey S; Warner, Matthew A et al. (2013) Effects of platelet and plasma transfusion on outcome in traumatic brain injury patients with moderate bleeding diatheses. J Neurosurg 118:676-86
Zafonte, Ross D; Bagiella, Emilia; Ansel, Beth M et al. (2012) Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: Citicoline Brain Injury Treatment Trial (COBRIT). JAMA 308:1993-2000
Hudak, A M; Hynan, L S; Harper, C R et al. (2012) Association of depressive symptoms with functional outcome after traumatic brain injury. J Head Trauma Rehabil 27:87-98
Wang, Jun Yi; Abdi, Herve; Bakhadirov, Khamid et al. (2012) A comprehensive reliability assessment of quantitative diffusion tensor tractography. Neuroimage 60:1127-38

Showing the most recent 10 out of 37 publications