This proposed study is a cooperative one involving two components of the University of Mississippi. We propose to enroll 225 borderline hypertensive individuals (DBP 85-95 mm Hg) who are moderately overweight (120-150% of ideal weight). They will then be enrolled in the following dietary change programs: 1) weight loss, 2) weight loss plus increased calcium, 3) weight loss plus increased exercise, and 4) weight loss plus increased potassium (the last condition only at the Jackson site). Participants who are to undergo the weight loss and exercise protocol will have determination of fitness (treadmill) made at baseline and at follow-up. The primary purpose of this phase of the study is to determine ability to change intervening variables. However, differences in blood pressure fall between the control group and each of the dietary and other change variables should be able to be determined, although clear differences between the dietary groups in blood pressure is unlikely to be seen. Studies of red cell flux will be done to see if these correlate with response to dietary change.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL037854-04
Application #
3552827
Study Section
(SRC)
Project Start
1986-09-30
Project End
1990-09-29
Budget Start
1989-07-01
Budget End
1990-09-29
Support Year
4
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Mississippi Medical Center
Department
Type
Schools of Medicine
DUNS #
928824473
City
Jackson
State
MS
Country
United States
Zip Code
39216
Cook, Nancy R; Appel, Lawrence J; Whelton, Paul K (2014) Lower levels of sodium intake and reduced cardiovascular risk. Circulation 129:981-9
Cook, Nancy R; Obarzanek, Eva; Cutler, Jeffrey A et al. (2009) Joint effects of sodium and potassium intake on subsequent cardiovascular disease: the Trials of Hypertension Prevention follow-up study. Arch Intern Med 169:32-40
Cook, Nancy R; Cutler, Jeffrey A; Obarzanek, Eva et al. (2007) Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP). BMJ 334:885-8
Kumanyika, S K; Cook, N R; Cutler, J A et al. (2005) Sodium reduction for hypertension prevention in overweight adults: further results from the Trials of Hypertension Prevention Phase II. J Hum Hypertens 19:33-45
Cook, N R; Kumanyika, S K; Cutler, J A et al. (2005) Dose-response of sodium excretion and blood pressure change among overweight, nonhypertensive adults in a 3-year dietary intervention study. J Hum Hypertens 19:47-54
Batey, D M; Kaufmann, P G; Raczynski, J M et al. (2000) Stress management intervention for primary prevention of hypertension: detailed results from Phase I of Trials of Hypertension Prevention (TOHP-I). Ann Epidemiol 10:45-58
Kumanyika, S K; Hebert, P R; Cutler, J A et al. (1993) Feasibility and efficacy of sodium reduction in the Trials of Hypertension Prevention, phase I. Trials of Hypertension Prevention Collaborative Research Group. Hypertension 22:502-12
Whelton, P K; Hebert, P R; Cutler, J et al. (1992) Baseline characteristics of participants in phase I of the Trials of Hypertension Prevention. Ann Epidemiol 2:295-310