Hypertension is a major risk factor for mortality and morbidity in the USA and most of the Western societies. Drug treatment of hypertension, although effective in reducing mortality and morbidity, is associated with untoward side effects. Because of the magnitude of the problem of hypertension and the inherent fallacy in a policy of using drugs exclusively to control hypertension, it seems prudent to test the efficacy of nonpharmacologic methods of intervention in our approach to primary prevention of hypertension. In this application, we have attempted to document our capability of recruiting 250 eligible participants for Phase II of TOHP and have presented methods of intervention we would like to test. These methods include weight reduction and sodium restriction. Participants will be assigned randomly to each of these groups and to a control group. Results in each group will be compared with a control group. The intervention method for dietary modification modality will include a combination of group sessions and individual counseling. The entire Protocol for Phase II of TOHP has been developed by the investigators who participated in TOHP - Phase I and based on the results of Phase I identified the optional intervention regimen (i.e., weight loss and sodium reduction).' The detailed Protocol is submitted as Appendix I.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL037904-07
Application #
3552867
Study Section
Special Emphasis Panel (SRC (ZZ))
Project Start
1986-09-30
Project End
1995-06-30
Budget Start
1992-07-01
Budget End
1993-06-30
Support Year
7
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of California Davis
Department
Type
Schools of Medicine
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618
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Cook, Nancy R; Obarzanek, Eva; Cutler, Jeffrey A et al. (2009) Joint effects of sodium and potassium intake on subsequent cardiovascular disease: the Trials of Hypertension Prevention follow-up study. Arch Intern Med 169:32-40
Cook, Nancy R; Cutler, Jeffrey A; Obarzanek, Eva et al. (2007) Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP). BMJ 334:885-8
Kumanyika, S K; Cook, N R; Cutler, J A et al. (2005) Sodium reduction for hypertension prevention in overweight adults: further results from the Trials of Hypertension Prevention Phase II. J Hum Hypertens 19:33-45
Cook, N R; Kumanyika, S K; Cutler, J A et al. (2005) Dose-response of sodium excretion and blood pressure change among overweight, nonhypertensive adults in a 3-year dietary intervention study. J Hum Hypertens 19:47-54
Yamamoto, M E; Applegate, W B; Klag, M J et al. (1995) Lack of blood pressure effect with calcium and magnesium supplementation in adults with high-normal blood pressure. Results from Phase I of the Trials of Hypertension Prevention (TOHP). Trials of Hypertension Prevention (TOHP) Collaborative Research Group Ann Epidemiol 5:96-107
Whelton, P K; Buring, J; Borhani, N O et al. (1995) The effect of potassium supplementation in persons with a high-normal blood pressure. Results from phase I of the Trials of Hypertension Prevention (TOHP). Trials of Hypertension Prevention (TOHP) Collaborative Research Group. Ann Epidemiol 5:85-95