The overall goal of this cooperative research program is to develop a multi-institutional research effort to address the mechanisms of postnatal lung pathobiology that lead to chronic lung disease and to provide a unique resource center of prematurely delivered baboons with induced bronchopulmonary dysplasia (BPD) to outstanding investigators from multiple institutions dedicated to sharing collaborative protocols and tissue specimens. In recent years, the original form of BPD described in the 1960's has become less common due to improvements in oxygenation and ventilatory strategies and the use of postnatal exogenous surfactant, and has been replaced by a less severe form of disease seen primarily in extremely small immature infants. The baboon models of BPD are unique in the world; they develop disease that is very similar, if not identical, to human disease but in a controlled environment. The Southwest Foundation for Biomedical Research and the University of Texas Health Science Center at San Antonio have the breeding colony and the scientific personnel to support the proposed BPD Resource Core.
The specific aims of the BPD Resource Core are: 1) To breed baboons to produce pregnancies of known gestational ages, and to deliver by caesarian section 100 timed pregnancies per year, to provide the premature infants that will be shared by multiple investigators. 2) To maintain these premature infant baboons in a neonatal intensive care environment for study periods of 6, 10, 14, or 21 days, utilizing several well-defined treatment protocols. 3) To provide tissue specimens taken at the time of delivery, during the animal's clinical course, and at necropsy in as ideal and timely a manner as possible, and tailored to each investigator's needs. 4) To provide a Data Management Core for animal information retrieval. This U-01 program brings together the enthusiasm and competence of established investigators with varying backgrounds and expertise who are committed to examining the various aspects of lung development and how, when interrupted, the fetus adapts to the extrauterine environment. It allows, at a national level, a continuing influx of outstanding scientists to address the major deficiencies in our knowledge concerning BPD.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL052636-12
Application #
6896389
Study Section
Special Emphasis Panel (ZHL1-CSR-P (S2))
Program Officer
Berberich, Mary Anne
Project Start
1994-07-20
Project End
2009-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
12
Fiscal Year
2005
Total Cost
$2,518,144
Indirect Cost
Name
University of Texas Health Science Center San Antonio
Department
Pathology
Type
Other Domestic Higher Education
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Shelton, Elaine L; Waleh, Nahid; Plosa, Erin J et al. (2018) Effects of antenatal betamethasone on preterm human and mouse ductus arteriosus: comparison with baboon data. Pediatr Res 84:458-465
Liao, Jie; Kapadia, Vishal S; Brown, L Steven et al. (2015) The NLRP3 inflammasome is critically involved in the development of bronchopulmonary dysplasia. Nat Commun 6:8977
Blanco, Cynthia L; McGill-Vargas, Lisa L; Gastaldelli, Amalia et al. (2015) Peripheral insulin resistance and impaired insulin signaling contribute to abnormal glucose metabolism in preterm baboons. Endocrinology 156:813-23
Blanco, Cynthia L; Moreira, Alvaro G; McGill-Vargas, Lisa L et al. (2014) Antenatal corticosteroids alter insulin signaling pathways in fetal baboon skeletal muscle. J Endocrinol 221:253-60
Yoder, Bradley A; Coalson, Jacqueline J (2014) Animal models of bronchopulmonary dysplasia. The preterm baboon models. Am J Physiol Lung Cell Mol Physiol 307:L970-7
Kerecman, Jay; Mehrotra, Anupamjit; Goodman, Zachary (2013) Liver disease after intensive care of premature baboons: histopathologic observations. J Pediatr Gastroenterol Nutr 57:172-9
Blanco, Cynthia L; McGill-Vargas, Lisa L; McCurnin, Donald et al. (2013) Hyperglycemia increases the risk of death in extremely preterm baboons. Pediatr Res 73:337-43
Quinn, Amy R; Blanco, Cynthia L; Perego, Carla et al. (2012) The ontogeny of the endocrine pancreas in the fetal/newborn baboon. J Endocrinol 214:289-99
Shields, Amy; Thomson, Merran; Winter, Vicki et al. (2012) Repeated courses of antenatal corticosteroids have adverse effects on aspects of brain development in naturally delivered baboon infants. Pediatr Res 71:661-7
Rees, Sandra; Loeliger, Michelle; Shields, Amy et al. (2011) The effects of postnatal estrogen therapy on brain development in preterm baboons. Am J Obstet Gynecol 204:177.e8-14

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