? ? The Family Blood Pressure Program [FBPP] is an unprecedented collaboration to identify genes influencing blood pressure levels, hypertension and its cardiovascular complications (hereafter referred to as """"""""hypertension genes""""""""). To date, the Program has carried out 21,600 physical examinations, assembled a shared database of 294 hypertension-relevant variables, measured quantitative echocardiograms on 7,321 individuals, carried-out genome-wide linkage analyses for hypertension status and 13 related phenotypes, published (or in press) 128 manuscripts and identified 5 hypertension susceptibility genes by following-up 4 linkage peaks. In the proposed next phase of the FBPP, a major emphasis is placed on making the Program a shared resource for hypertension researchers in the United States and throughout the world.
In Aim 1, we will build, maintain and update a publicly available knowledge-base to facilitate research by non-FBPP investigators on the genetics of hypertension, its risk factors and its complications.
In Aim 2, we will use state-of-the-art genetic linkage analysis methods to identify additional linkage regions using subgroups of pedigrees and physiologically relevant combinations of phenotypes that will aid in localizing hypertension genes.
In Aim 3, we will use a combination of bioinformatics, a dense array of SNPs, and state-of-the-art ? data analysis to follow-up regions of interest and identify the underlying hypertension genes. The regions to be followed-up include those identified during the current phase of the FBPP and Aim 2 of this renewal phase.
In Aim 4, we will evaluate the hypertension genes identified in Aim 3 for their association with multiple measures reflecting the cardiovascular and renal complications of hypertension, including left ventricular mass and microalbuminuria. It is the long-term goal of the FBPP to have the hypertension genetics community develop a comprehensive picture of the genetic architecture of human hypertension, including its risk factors, complications, and response to treatment. ? (End of Abstract) ? ?

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
2U01HL054512-11
Application #
6951641
Study Section
Special Emphasis Panel (ZHL1-CSR-L (M1))
Program Officer
Paltoo, Dina
Project Start
1995-09-05
Project End
2008-08-31
Budget Start
2005-09-30
Budget End
2006-08-31
Support Year
11
Fiscal Year
2005
Total Cost
$857,224
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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Brown, Catherine M; Turner, Stephen T; Bailey, Kent R et al. (2013) Hypertension in pregnancy is associated with elevated C-reactive protein levels later in life. J Hypertens 31:2213-9; discussion 2219
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White, Wendy M; Turner, Stephen T; Bailey, Kent R et al. (2013) Hypertension in pregnancy is associated with elevated homocysteine levels later in life. Am J Obstet Gynecol 209:454.e1-7
Monda, Keri L; Chen, Gary K; Taylor, Kira C et al. (2013) A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet 45:690-6

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