Abstract

) FHS: Molecular Genetics and Genetic Epidemiology is submitted collaboratively by seven research groups including four clinical sites (University of North Carolina; Boston University; University of Minnesota; and University of Utah), a molecular biology laboratory (University of Utah), a coordinating center (Washington University, St. Louis, MO), a chemistry laboratory (University of Minnesota). The proposed study will perform state-of-the-art molecular genetic and genetic epidemiology studies using the extensive data on family and medical histories, risk factors, life style, blood specimens and banked DNA, previously collected by the Family Heart Study (FHS). The purpose is to identify and characterize genes of coronary heart disease (CHD) and atherosclerosis, familial environmental factors and behavioral characteristics, and to advance our understanding of how they interact with one another in the development of clinical outcomes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL056567-04
Application #
6043906
Study Section
Special Emphasis Panel (ZHL1-CSR-R (O1))
Project Start
1996-08-15
Project End
2001-07-31
Budget Start
1999-08-01
Budget End
2001-07-31
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Biostatistics & Other Math Sci
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Nielson, Carrie M; Liu, Ching-Ti; Smith, Albert V et al. (2016) Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2. J Bone Miner Res 31:2085-2097
Holohan, Brody; De Meyer, Tim; Batten, Kimberly et al. (2015) Decreasing initial telomere length in humans intergenerationally understates age-associated telomere shortening. Aging Cell 14:669-77
Robbins, Jeremy M; Petrone, Andrew B; Carr, J Jeffrey et al. (2015) Association of ideal cardiovascular health and calcified atherosclerotic plaque in the coronary arteries: the National Heart, Lung, and Blood Institute Family Heart Study. Am Heart J 169:371-378.e1
Lai, Lana Y H; Petrone, Andrew B; Pankow, James S et al. (2015) Lack of association of apolipoprotein E (Apo E) polymorphism with the prevalence of metabolic syndrome: the National Heart, Lung and Blood Institute Family Heart Study. Diabetes Metab Res Rev 31:582-7
Hunt, Steven C; Kimura, Masayuki; Hopkins, Paul N et al. (2015) Leukocyte telomere length and coronary artery calcium. Am J Cardiol 116:214-8
Lai, Y H Lana; Petrone, Andrew B; Pankow, James S et al. (2013) Association of dietary omega-3 fatty acids with prevalence of metabolic syndrome: the National Heart, Lung, and Blood Institute Family Heart Study. Clin Nutr 32:966-9
Grove, Megan L; Yu, Bing; Cochran, Barbara J et al. (2013) Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium. PLoS One 8:e68095
Tokede, Oluwabunmi A; Ellison, Curtis R; Pankow, James S et al. (2012) Chocolate consumption and prevalence of metabolic syndrome in the NHLBI Family Heart Study. ESPEN J 7:e139-e143
Rahilly-Tierney, Catherine R; Arnett, Donna K; North, Kari E et al. (2011) Apolipoprotein ?4 polymorphism does not modify the association between body mass index and high-density lipoprotein cholesterol: a cross-sectional cohort study. Lipids Health Dis 10:167
Arbeev, Konstantin G; Hunt, Steven C; Kimura, Masayuki et al. (2011) Leukocyte telomere length, breast cancer risk in the offspring: the relations with father's age at birth. Mech Ageing Dev 132:149-53

Showing the most recent 10 out of 59 publications