In this response to NHLBI RFA Number HL-98-010, we propose, as a field center: In Phase I: To conduct a two year intervention planning phase to: (a) identify potentially modifiable social and behavioral determinants of the behaviors and processes that will form the core of the intervention program, particularly those that may have been previously unrecognized or that have different characteristics in African American girls than would be assumed based on studies in Euro American girls; (b) identify important contextual variables (e.g., cultural, situational, familial, or developmental factors that will clearly influence adoption and long term adherence, but which cannot be directly addressed by the intervention) and specify their implications for the intervention design and implementation; (c) for both the social/behavioral and contextual variables, distinguish between cultural variables that are common to African Americans across socioeconomic status from those that seem to apply primarily to high or low SES girls or their families, in order to clarify what differences in assumptions and approaches would apply to interventions stratified or not-stratified on SES; (d) refine proposed data collection methods to improve the validity and appropriateness of all measures for pre-pubertal African American girls, considering physiological and cognitive development, body composition issues, and psychosocial factors; (e) revise the proposed design, recruitment, intervention, and measurement plans as indicated; and (f) feasibility test all aspects in a formal 12 week pilot study with participants similar to those to be included in the Phase II study. In Phase II: To conduct a two year (Phase II) randomized clinical trial of two family-based interventions compared to a standard care condition. The primary outcome measure will be the between group differences in BMI and DEXA at 1 and 2 years of follow up. Secondary outcomes will be percent body fat, fasting insulin, glucose, and c-peptides. Intermediate outcome measures will include between group differences in dietary intake and physical activity. Measures of intervention safety and potential negative side effects of intervention will include measures of bone mass, sexual maturation, eating disorders, and rates of smoking. Because the type of intervention that will be effective will involve an interactive process of tailoring and responding to participant needs and interests, rather than fixed content offered in a fixed format, an additional aim of Phase II will be to document the interventions to allow for later dissemination. This will be accomplished through continued monitoring of the implementation process and development of a scheme for describing how the process evolves and how it can be replicated.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01HL062662-01S1
Application #
6139642
Study Section
Special Emphasis Panel (ZHL1 (F1))
Project Start
1999-08-01
Project End
2002-05-31
Budget Start
1999-08-01
Budget End
2000-03-31
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Memphis
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
City
Memphis
State
TN
Country
United States
Zip Code
38152
Hare, Marion E; Sherrill-Mittleman, Deborah; Klesges, Robert C et al. (2012) Energy underreporting in African-American girls: a longitudinal analysis. Child Obes 8:551-60
Stockton, Michelle B; McClanahan, Barbara S; Lanctot, Jennifer Q et al. (2012) Identification of facilitators and barriers to participation in weight gain prevention research by African American girls. Contemp Clin Trials 33:38-45
Dalton, William T; Klesges, Lisa M; Sherrill-Mittleman, Deborah et al. (2011) Family context as it relates to weight-related behaviors in preadolescent African American girls. Am J Health Behav 35:269-79
Klesges, Robert C; Obarzanek, Eva; Kumanyika, Shiriki et al. (2010) The Memphis Girls' health Enrichment Multi-site Studies (GEMS): an evaluation of the efficacy of a 2-year obesity prevention program in African American girls. Arch Pediatr Adolesc Med 164:1007-14
Sherrill-Mittleman, D A; Klesges, L M; Lanctot, J Q et al. (2009) Measurement characteristics of dietary psychosocial scales in a Weight Gain Prevention Study with 8- to 10-year-old African-American girls. Health Educ Res 24:586-95
McClanahan, Barbara S; Stockton, Michelle B; Lanctot, Jennifer Q et al. (2009) Measurement of body composition in 8-10-year-old African-American girls: a comparison of dual-energy X-ray absorptiometry and foot-to-foot bioimpedance methods. Int J Pediatr Obes 4:389-96
Reddy, Jagadeshwar G; Ebbert, Jon O; Klesges, Lisa M et al. (2008) The relationship between caffeine and blood pressure in preadolescent African American girls. Ethn Dis 18:283-8
Klesges, Robert C; Obarzanek, Eva; Klesges, Lisa M et al. (2008) Memphis Girls health Enrichment Multi-site Studies (GEMS): Phase 2: design and baseline. Contemp Clin Trials 29:42-55
Dalton 3rd, William T; Klesges, Lisa M; Beech, Bettina M et al. (2007) Comparisons between African American girls'and parents'perceptions of girls'weight concerns and weight control behaviors. Eat Disord 15:231-46
Himes, John H; Obarzanek, Eva; Baranowski, Tom et al. (2004) Early sexual maturation, body composition, and obesity in African-American girls. Obes Res 12 Suppl:64S-72S

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