Inflammation is one of the most basic responses linked to a wide variety of common human disorders including asthma, chronic obstructive pulmonary disease, coronary artery disease and stroke. In this application, the investigators propose a joint program between the University of Washington and the Fred Hutchinson Cancer Research Center (UW-FHCRC) to establish a Variation Discovery Resource (VDR) focused on finding single nucleotide polymorphisms (SNPs) in the genes and pathways underlying inflammatory responses in humans. The goals are: (1) to establish a high throughput variation discovery group that will scan more than 200 of the genes involved in inflammation; (2) to identify the common variable sites, their relative frequencies, and haplotypes in these genes for two populations having different evolutionary historics; (3) to rapidly disseminate this information to the biomedical community via national databases such as dbSNP and Genbank, and by a resource generated website; and (4) to establish a training and education program on human variation analysis that provides on-site training as well as a formalized workshop. Overall, the studies will provide a wealth of new information for testing the important relationships that exist between variations in human DNA sequence, and variations in risk for common human diseases.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL066642-04
Application #
6651047
Study Section
Special Emphasis Panel (ZHL1-CSR-L (S2))
Program Officer
Ye, Jane
Project Start
2000-09-30
Project End
2004-07-31
Budget Start
2003-08-01
Budget End
2004-07-31
Support Year
4
Fiscal Year
2003
Total Cost
$233,467
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
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