Abstract

This application if for the Harvard Vanguard Medical Associates (HVMA) to participate in the Childhood Asthma Management Program Continuation Study/Phase 2 (CAMPCS/2). The abstract and, research p_a0 for CAMPCS/2 are included in the application for the Washington University (Robert Strunk, PI). This HVMA clinic is committed to participating in CAMPCS/2 and supports the continued follow up of CAMP patients. We will continue to collect data of high quality. We enrolled 124 patients in CAMP and enrolled 115 patients in CAMPCS. The families and patients of CAMPCS continue to be committed to the study and we anticipate their continued involvement through CAMPCS/2. We have successfully recruited 94% of the original CAMP cohort into CAMPCS, and we will continue to recruit the original CAMP cohort for CAMPCS/2. Participation in CAMPCS has been excellent with 94-97% of patients completing CAMPCS study visits for which the completion window has closed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01HL075419-01
Application #
6718060
Study Section
Clinical Trials Review Committee (CLTR)
Program Officer
Taggart, Virginia
Project Start
2003-09-30
Project End
2007-06-30
Budget Start
2003-09-30
Budget End
2004-06-30
Support Year
1
Fiscal Year
2003
Total Cost
$203,274
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

McGeachie, Michael J; Yates, Katherine P; Zhou, Xiaobo et al. (2016) Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma. Am J Respir Crit Care Med 194:1465-1474
Park, Heung-Woo; Song, Woo-Jung; Chang, Yoon-Suk et al. (2016) Bronchodilator response following methacholine-induced bronchoconstriction predicts acute asthma exacerbations. Eur Respir J 48:104-14
Howrylak, Judie A; Moll, Matthew; Weiss, Scott T et al. (2016) Gene expression profiling of asthma phenotypes demonstrates molecular signatures of atopy and asthma control. J Allergy Clin Immunol 137:1390-1397.e6
Pino-Yanes, Maria; Gignoux, Christopher R; Galanter, Joshua M et al. (2015) Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos. J Allergy Clin Immunol 135:1502-10
Brehm, John M; Ramratnam, Sima K; Tse, Sze Man et al. (2015) Stress and Bronchodilator Response in Children with Asthma. Am J Respir Crit Care Med 192:47-56
Schildcrout, Jonathan S; Rathouz, Paul J; Zelnick, Leila R et al. (2015) BIASED SAMPLING DESIGNS TO IMPROVE RESEARCH EFFICIENCY: FACTORS INFLUENCING PULMONARY FUNCTION OVER TIME IN CHILDREN WITH ASTHMA. Ann Appl Stat 9:731-753
Israel, Elliot; Lasky-Su, Jessica; Markezich, Amy et al. (2015) Genome-wide association study of short-acting ?2-agonists. A novel genome-wide significant locus on chromosome 2 near ASB3. Am J Respir Crit Care Med 191:530-7
Strunk, Robert C; Colvin, Ryan; Bacharier, Leonard B et al. (2015) Airway Obstruction Worsens in Young Adults with Asthma Who Become Obese. J Allergy Clin Immunol Pract 3:765-71.e2
Brehm, John M; Man Tse, Sze; Croteau-Chonka, Damien C et al. (2015) A Genome-Wide Association Study of Post-bronchodilator Lung Function in Children with Asthma. Am J Respir Crit Care Med 192:634-7
Bunyavanich, Supinda; Schadt, Eric E; Himes, Blanca E et al. (2014) Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis. BMC Med Genomics 7:48

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