?????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL081341-03
Application #
7253332
Study Section
Special Emphasis Panel (ZHL1-CSR-K (M1))
Program Officer
Srinivas, Pothur R
Project Start
2005-08-25
Project End
2009-06-30
Budget Start
2007-07-16
Budget End
2008-06-30
Support Year
3
Fiscal Year
2007
Total Cost
$1,520,680
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
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Addona, Terri A; Shi, Xu; Keshishian, Hasmik et al. (2011) A pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease. Nat Biotechnol 29:635-43
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Sherwood, Matthew W; Morrow, David A; Scirica, Benjamin M et al. (2010) Early dynamic risk stratification with baseline troponin levels and 90-minute ST-segment resolution to predict 30-day cardiovascular mortality in ST-segment elevation myocardial infarction: analysis from CLopidogrel as Adjunctive ReperfusIon TherapY (CLAR Am Heart J 159:964-971.e1
Deo, Rahul C; Hunter, Luke; Lewis, Gregory D et al. (2010) Interpreting metabolomic profiles using unbiased pathway models. PLoS Comput Biol 6:e1000692
Cenik, Can; Derti, Adnan; Mellor, Joseph C et al. (2010) Genome-wide functional analysis of human 5' untranslated region introns. Genome Biol 11:R29
Rudomin, Emily L; Carr, Steven A; Jaffe, Jacob D (2009) Directed sample interrogation utilizing an accurate mass exclusion-based data-dependent acquisition strategy (AMEx). J Proteome Res 8:3154-60
Deo, Rahul C; Roth, Frederick P (2009) Pathways of the heart. Circ Cardiovasc Genet 2:303-5
Fusaro, Vincent A; Mani, D R; Mesirov, Jill P et al. (2009) Prediction of high-responding peptides for targeted protein assays by mass spectrometry. Nat Biotechnol 27:190-8

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