? ? Over 5 million people suffer from heart failure (HF) and 250,000 die annually, despite new medications and devices. Uniting strengths from diverse HF sites through the NHLBI, the National Heart Failure Network is vital to accelerate conceptual HF research and apply it to improve quality and length of life with HF. This proposal from Partners Heart Failure Program demonstrates dedication and expertise for improving HF outcomes, centered in HF clinics of Brigham and Women's and Massachusetts General Hospitals, enhanced by established collaboration with the Chabert HF site enrolling rural indigent patients in Louisiana. This represents 800 new patients and 5100 visits annually and 330 trial subjects the past 2 years. Expanded circles include 4 other Boston HF sites, 6 other Louisiana sites, and Partners Research and Education Program (PREP) supporting office-based clinical trials for 25 Boston community physicians. Objectives are: ? 1*) Facilitate establishment of an effective national network for research to improve outcomes in heart failure; with Two Major Aims: To contribute strong, diverse subject enrollment and to facilitate HF protocol design. Project A offers a template to assess the impact of regenerative therapy for late-stage HF, using catheter transfection of adeno-associated virus/SERCA2a protein. Project B provides a template for a 3-way trial of acute therapy in decompensated HF, comparing hormonal and mechanical to diuretic strategies for the cardiorenal syndrome. We advocate also the creation of two Vital Network Assets: a Parallel Advanced Registry to compare with VAD patients as the first Parallel Cohort analysis, and a Heart Failure DNA /Tissue Repository. 2*) Create the supportive matrix of senior, emerging, and junior investigators, with Training Core focus on rigorous didactics and diverse hands-on experiences to nurture the next generation of investigators. 3*) Enhance dissemination of network progress into community channels. Major strengths of this proposal are 1) breadth of expertise in clinical HF and relevant basic science; 2) enhanced value from institutional commitments to infrastructure at 3 sites and PREP; 3) real-time patient profiles for proven urban and rural enrollment; 4) focus on assessing strategies in advanced HF; 5) innovation into gene-based therapy for myocardial regeneration; and 6) successful precedent of inclusive collaboration for regional HF care and education and national NHLBI initiatives such as REMATCH, ESCAPE, and the National VAD Registry. (End of Abstract) ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL084877-02
Application #
7289782
Study Section
Special Emphasis Panel (ZHL1-CSR-H (M1))
Program Officer
Mascette, Alice
Project Start
2006-09-30
Project End
2011-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
2
Fiscal Year
2007
Total Cost
$581,746
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
AbouEzzeddine, Omar F; McKie, Paul M; Dunlay, Shannon M et al. (2017) Suppression of Tumorigenicity 2 in Heart Failure With Preserved Ejection Fraction. J Am Heart Assoc 6:
Gilstrap, Lauren G; Snipelisky, David; AbouEzzeddine, Omar et al. (2017) Unanswered Questions in Contemporary Heart Failure. J Card Fail 23:770-774
Grodin, Justin L; Sun, Jie-Lena; Anstrom, Kevin J et al. (2017) Implications of Serum Chloride Homeostasis in Acute Heart Failure (from ROSE-AHF). Am J Cardiol 119:78-83
Gilstrap, Lauren G; DeFilippis, Ersilia M; Stevenson, Lynne W (2017) An Unintended Consequence of the 21st-Century Cures Act for Patients With Heart Failure. Circulation 136:123-125
Gandhi, Parul U; Gaggin, Hanna K; Redfield, Margaret M et al. (2016) Insulin-Like Growth Factor-Binding Protein-7 as a Biomarker of Diastolic Dysfunction and Functional Capacity in Heart Failure With Preserved Ejection Fraction: Results From the RELAX Trial. JACC Heart Fail 4:860-869
Butler, Javed; Hernandez, Adrian F; Anstrom, Kevin J et al. (2016) Rationale and Design of the ATHENA-HF Trial: Aldosterone Targeted Neurohormonal Combined With Natriuresis Therapy in Heart Failure. JACC Heart Fail 4:726-35
Shah, Ravi V; Murthy, Venkatesh L; Abbasi, Siddique A et al. (2015) Weight loss and progressive left ventricular remodelling: The Multi-Ethnic Study of Atherosclerosis (MESA). Eur J Prev Cardiol 22:1408-18
Stevenson, Lynne Warner (2015) Crisis Awaiting Heart Transplantation: Sinking the Lifeboat. JAMA Intern Med 175:1406-9
Lala, Anuradha; McNulty, Steven E; Mentz, Robert J et al. (2015) Relief and Recurrence of Congestion During and After Hospitalization for Acute Heart Failure: Insights From Diuretic Optimization Strategy Evaluation in Acute Decompensated Heart Failure (DOSE-AHF) and Cardiorenal Rescue Study in Acute Decompensated Heart Circ Heart Fail 8:741-8
AbouEzzeddine, Omar F; Haines, Phillip; Stevens, Susanna et al. (2015) Galectin-3 in heart failure with preserved ejection fraction. A RELAX trial substudy (Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure). JACC Heart Fail 3:245-52

Showing the most recent 10 out of 35 publications