The regeneration of human bone marrow from transplantation is now a common medical practice in the United States. Although stem cells resident in cardiac tissues and pulmonary tissues have been identified in humans, much remains to be learned about stem cell and progenitor cell biology in these tissues and in the bone marrow. A Consortium (the NHLBI Progenitor Cell Biology Consortium) could take advantage of recent developments (discoveries, technologies and reagents) to Identify and characterize progenitor cell lineages, to direct the differentiation of stem and progenitor cells and to address the challenges of transplanting those cells to translate into treatments in the regenerative biology and medicine armamentarium. An Administrative Coordinating Center (ACC) is necessary for this Consortium to achieve its goals of applying advances in stem and progenitor cell biology to advance the identity of cardiovascular, lung and blood diseases. The proposed ACC has the knowledgeable and experienced faculty and staff and a plan to provide outstanding administrative and technical support to the NHLBI Progenitor Cell Biology Consortium. The proposed ACC has a strong track record in and will organize meeting and conference calls, maintain written documents and a website, award subcontracts, oversee review and award of pilot and ancillary study funds, and process those studies, renewals and reports. The communications and professorial (instructional) strengths of the proposed ACC will enhance coordination of skills development activities. By bringing together collaborating groups of progenitor cell biology investigators and their data, organizing communications and information, and disseminating findings, the ACC will make an important contribution to the success of the NHLBI Progenitor Cell Biology Consortium.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL099997-03
Application #
8105340
Study Section
Special Emphasis Panel (ZHL1-CSR-J (S2))
Program Officer
Buxton, Denis B
Project Start
2009-09-30
Project End
2016-04-30
Budget Start
2011-05-01
Budget End
2012-04-30
Support Year
3
Fiscal Year
2011
Total Cost
$2,228,983
Indirect Cost
Name
University of Maryland Baltimore
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Miyaoka, Yuichiro; Mayerl, Steven J; Chan, Amanda H et al. (2018) Detection and Quantification of HDR and NHEJ Induced by Genome Editing at Endogenous Gene Loci Using Droplet Digital PCR. Methods Mol Biol 1768:349-362
Cho, Ukrae; Riordan, Daniel P; Ciepla, Paulina et al. (2018) Ultrasensitive optical imaging with lanthanide lumiphores. Nat Chem Biol 14:15-21
Magella, Bliss; Adam, Mike; Potter, Andrew S et al. (2018) Cross-platform single cell analysis of kidney development shows stromal cells express Gdnf. Dev Biol 434:36-47
Hadland, Brandon; Yoshimoto, Momoko (2018) Many layers of embryonic hematopoiesis: new insights into B-cell ontogeny and the origin of hematopoietic stem cells. Exp Hematol 60:1-9
Huang, Ngan F; Serpooshan, Vahid; Morris, Viola B et al. (2018) Big bottlenecks in cardiovascular tissue engineering. Commun Biol 1:199
McCauley, Katherine B; Alysandratos, Konstantinos-Dionysios; Jacob, Anjali et al. (2018) Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium. Stem Cell Reports 10:1579-1595
Qin, Xulei; Chen, Haodong; Yang, Huaxiao et al. (2018) Photoacoustic Imaging of Embryonic Stem Cell-Derived Cardiomyocytes in Living Hearts with Ultrasensitive Semiconducting Polymer Nanoparticles. Adv Funct Mater 28:
Mills, Jason A; Herrera, Pamela S; Kaur, Maninder et al. (2018) NIPBL+/- haploinsufficiency reveals a constellation of transcriptome disruptions in the pluripotent and cardiac states. Sci Rep 8:1056
Daily, Kenneth; Ho Sui, Shannan J; Schriml, Lynn M et al. (2017) Molecular, phenotypic, and sample-associated data to describe pluripotent stem cell lines and derivatives. Sci Data 4:170030
Zimmermann, Wolfram-Hubertus (2017) Remuscularization of the failing heart. J Physiol 595:3685-3690

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