The purpose of this application is to establish the Lung and HIV Analytical Data Coordinating Center (LHAD- CC) that will collaborate with the research sites funded under the companion FOA RFA-HL-13-026. Together, our sites will form a new collaborative network (HLDN). LHAD-CC will provide leadership in contributing scientific leadership and epidemiological, statistical, genetic, clinical, and basic pulmonary research expertise while providing essential support for the success of the HLDN including coordination of the research network (e.g. facilitating collaborations, arranging meetings, specimen tracking), data management for the research network (e.g. establishment of a stable and efficient web-based data management system, quality control, and data harmonization), and analytical support for collaborative projects.
The specific aims of LHAD-CC are: (1) To provide scientific leadership for the HLDN in developing novel methodology;(2) To optimize the contributions of the network for HLDN in the understanding of the pathogenesis of lung disease in an era of effective treatment of HIV through collaboration and scientific partnership;(3) To coordinate research initiatives and scientific presentations;to facilitate communication amongst network investigators, Working Groups and committees;to orchestrate study protocol development;and to disseminate key scientific findings (Dossier, Archives, &Study Website);(4) To adapt, maintain, and refine our current stable and efficient web- based data management system to the needs of HLDN. We will tailor our current systems for: tracking the storage and transfer of biological specimens at a central repository, producing annual public data sets, and conducting training in methods in order to facilitate the appropriate use of study data for local research;(5 To implement a quality assurance program in partnership with the clinical sites that integrates expertise in data management, study coordination, statistical methodology, and scientific disciplines. This program will monitor study-wide quality and promote adherence and training for data collection.
Our team has successfully served as the data management and analysis center for other ongoing large studies (e.g. Multicenter AIDS Cohort Study, North American AIDS Cohort Collaboration on Research and Design, the Women's Interagency HIV Study). We will bring this substantial expertise in establishing a successful data coordinating center for the clinical and basic research sites investigating the mechanisms of HIV-related lung disease. Through our efforts and that of the clinical and basic research site investigators, we wil advance clinical and basic science investigations in understanding lung diseases in HIV infected individuals.
| Lau, Bryan; Lesko, Catherine (2018) Missingness in the Setting of Competing Risks: from missing values to missing potential outcomes. Curr Epidemiol Rep 5:153-159 |
| Lesko, Catherine R; Buchanan, Ashley L; Westreich, Daniel et al. (2018) The Authors Respond. Epidemiology 29:e14-e15 |
| Lesko, Catherine R; Edwards, Jessie K; Cole, Stephen R et al. (2018) When to Censor? Am J Epidemiol 187:623-632 |
| Calkins, Keri L; Canan, Chelsea E; Moore, Richard D et al. (2018) An application of restricted mean survival time in a competing risks setting: comparing time to ART initiation by injection drug use. BMC Med Res Methodol 18:27 |
| Lesko, Catherine R; Keil, Alexander P; Moore, Richard D et al. (2018) Measurement of Current Substance Use in a Cohort of HIV-Infected Persons in Continuity HIV Care, 2007-2015. Am J Epidemiol 187:1970-1979 |
| Lesko, Catherine R; Jacobson, Lisa P; Althoff, Keri N et al. (2018) Collaborative, pooled and harmonized study designs for epidemiologic research: challenges and opportunities. Int J Epidemiol 47:654-668 |
| Canan, Chelsea; Lesko, Catherine; Lau, Bryan (2017) Instrumental Variable Analyses and Selection Bias. Epidemiology 28:396-398 |
| Lesko, Catherine R; Todd, Jonathan V; Cole, Stephen R et al. (2017) Mortality under plausible interventions on antiretroviral treatment and depression in HIV-infected women: an application of the parametric g-formula. Ann Epidemiol 27:783-789.e2 |
| Presti, Rachel M; Flores, Sonia C; Palmer, Brent E et al. (2017) Mechanisms Underlying HIV-Associated Noninfectious Lung Disease. Chest 152:1053-1060 |
| Lesko, Catherine R; Buchanan, Ashley L; Westreich, Daniel et al. (2017) Generalizing Study Results: A Potential Outcomes Perspective. Epidemiology 28:553-561 |
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