This is a proposal for the NIMH Collaborative Program on the Psychobiology of Depression (""""""""the Collaborative Depression Study""""""""). The purpose of this application for the Cooperative Agreement is to continue the collaborative effort of a group senior investigators and the NIMH that has functioned smoothly, efficiently, and productively for over a decade. The Cooperative Agreement application requests support for the maintenance of the infrastructure of communication and administration of the Collaborative Depression Study. This infrastructure will ensure continued scientific integrity of the Collaborative Depression Study, protect its sample and data base, and provide ongoing policy and organization for analysis of data and publication of results. The Cooperative Agreement will provide funds to support the Clinical Studies Committee which is the executive body for the Collaborative Depression Study and is vested with responsibility for all major policy and operational decisions. The Cooperative Agreement will also support the Publication Committee which has authority over presentation and publication of all data emanating from more than one center. This committee reviews proposed analyses, abstracts, manuscripts, etc. to assure adequate sharing of data and quality control. Finally, the Cooperative Agreement will support Cluster Committees, which are organized around functional tasks in substantive areas, and serve to plan and execute important activities of the Collaborative Depression Study. These committees are responsible for making recommendations regarding plans and explication of issues, assessment of alternatives and the conduct of data analyses in each area.
| Klerman, G L; Leon, A C; Wickramaratne, P et al. (1996) The role of drug and alcohol abuse in recent increases in depression in the US. Psychol Med 26:343-51 |
| Leon, A C; Klerman, G L; Wickramaratne, P (1993) Continuing female predominance in depressive illness. Am J Public Health 83:754-7 |
| Weissman, M M; Klerman, G L (1992) Depression: current understanding and changing trends. Annu Rev Public Health 13:319-39 |
| Leon, A C; Klerman, G L; Weissman, M M et al. (1992) Evaluating the diagnostic criteria for panic disorder: measures of social morbidity as criteria. Soc Psychiatry Psychiatr Epidemiol 27:180-4 |
| Mitchell, J E; Fletcher, L; Gibeau, L et al. (1992) Shoplifting in bulimia nervosa. Compr Psychiatry 33:342-5 |
| Mitchell, J E; Pyle, R L; Hatsukami, D et al. (1991) Enema abuse as a clinical feature of bulimia nervosa. Psychosomatics 32:102-4 |
| Klerman, G L; Weissman, M M; Ouellette, R et al. (1991) Panic attacks in the community. Social morbidity and health care utilization. JAMA 265:742-6 |
| Klerman, G L (1989) Depressive disorders. Further evidence for increased medical morbidity and impairment of social functioning. Arch Gen Psychiatry 46:856-8 |
| Klerman, G L; Weissman, M M (1989) Increasing rates of depression. JAMA 261:2229-35 |
| Mirowsky, J; Ross, C E (1989) Psychiatric diagnosis as reified measurement. J Health Soc Behav 30:11-25;discussion 26-40 |
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