Abstract

This project from the Johns Hopkins University Department of Psychiatry in response to an NIMH Request for Applications seeks to develop a Diagnostic Center for Linkage Studies of Bipolar Affective Disorder. The project will be part of a cooperative agreement program involving active collaboration of NIMH staff and other diagnostic centers. The project will aim to develop, in the context of the collaboration, an appropriate plan for use of small families with highly informative family structures for linkage studies, to find and recruit 66 such bipolar families to the study, to develop and carry our clinical diagnostic protocol to classify the affected and unaffected phenotypes in the bipolar families, and to collect and ship to a central facility blood samples for lymphocyte transformation into permanent cell lines for DNA based linkage studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01MH046274-08
Application #
2246975
Study Section
Special Emphasis Panel (SRCM (03))
Project Start
1989-09-30
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1998-08-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Leonpacher, A K; Liebers, D; Pirooznia, M et al. (2015) Distinguishing bipolar from unipolar depression: the importance of clinical symptoms and illness features. Psychol Med 45:2437-46
Graae, Lisette; Paddock, Silvia; Belin, Andrea Carmine (2015) ReMo-SNPs: a new software tool for identification of polymorphisms in regions and motifs genome-wide. Genet Res (Camb) 97:e8
Swaminathan, Shanker; Koller, Daniel L; Foroud, Tatiana et al. (2015) Characteristics of Bipolar I patients grouped by externalizing disorders. J Affect Disord 178:206-14
Jacobsen, Kaya K; Nievergelt, Caroline M; Zayats, Tetyana et al. (2015) Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder. J Affect Disord 172:453-61
Monahan, P O; Stump, T; Coryell, W H et al. (2015) Confirmatory test of two factors and four subtypes of bipolar disorder based on lifetime psychiatric co-morbidity. Psychol Med 45:2181-96
Winham, Stacey J; Cuellar-Barboza, Alfredo B; McElroy, Susan L et al. (2014) Bipolar disorder with comorbid binge eating history: a genome-wide association study implicates APOB. J Affect Disord 165:151-8
Li, Cong; Yang, Can; Gelernter, Joel et al. (2014) Improving genetic risk prediction by leveraging pleiotropy. Hum Genet 133:639-50
Bigdeli, T Bernard; Maher, Brion S; Zhao, Zhongming et al. (2013) Association study of 83 candidate genes for bipolar disorder in chromosome 6q selected using an evidence-based prioritization algorithm. Am J Med Genet B Neuropsychiatr Genet 162B:898-906
Greenwood, Tiffany A; Bipolar Genome Study (BiGS) Consortium; Kelsoe, John R (2013) Genome-wide association study of irritable vs. elated mania suggests genetic differences between clinical subtypes of bipolar disorder. PLoS One 8:e53804
Graae, Lisette; Karlsson, Robert; Paddock, Silvia (2012) Significant association of estrogen receptor binding site variation with bipolar disorder in females. PLoS One 7:e32304

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