This application proposes participation in the NIIMH cooperative agreement to establish Diagnostic Centers for Psychiatric Linkage Studies. In particular, it proposes participation in family studies of schizophrenia. Specifically, 66 families in which at least two sibs are diagnosed as schizophrenic according to DSM-IIIR criteria will be studied during years 2-4 of the proposed five year award. This application has several special strengths. It would be complemented and sponsored by an NIMH Clinical Research Center in psychiatric genetics. The principal investigators have extensive experience in the diagnosis and inheritance of schizophrenia, as well as the design and execution of linkage studies. The expertise of the investigators in psychiatric genetics in general, and schizophrenia in particular, would be useful to the proposed cooperative agreement between NIMH and several extramural sites.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01MH046276-05
Application #
3553892
Study Section
Special Emphasis Panel (SRCM (10))
Project Start
1989-09-30
Project End
1994-08-31
Budget Start
1993-09-01
Budget End
1994-08-31
Support Year
5
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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(2018) Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat Genet 50:668-681
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