Abstract

In response to RFA-NS-NS-05-001, we propose to establish a Parkinson's Disease Data Organizing Center (PD-DOC) at the University of Rochester. In keeping with the RFA, the PD-DOC will: 1) establish, maintain and disseminate a shared, central and standardized longitudinal database in support of the _rospective collection and analysis of clinical, neuropathological and biologic data from patients with PD and ;ontrols, 2) assess and move toward the potential integration of relevant pre-existing databases, 3) assist investigators planning to perform research studies using the shared database, 4) prepare and maintain an up-to-date catalog of research materials at participating sites that might be used for PD research and, 5) coordiante annual meetings of the PD-DOC Steering Committee. The University of Rochester has extensive expertise and resources which will facilitate the development of a highly successful PD-DOC. The PD-DOC will be a critical force in advancing collaborative research in PD.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01NS050095-03S1
Application #
7498641
Study Section
Special Emphasis Panel (ZNS1-SRB-K (12))
Program Officer
Murphy, Diane
Project Start
2004-09-30
Project End
2009-12-31
Budget Start
2007-01-01
Budget End
2007-12-31
Support Year
3
Fiscal Year
2007
Total Cost
$65,000
Indirect Cost

  Institution

Name
University of Rochester
Department
Neurology
Type
Schools of Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Liu, Ganqiang; Locascio, Joseph J; Corvol, Jean-Christophe et al. (2017) Prediction of cognition in Parkinson's disease with a clinical-genetic score: a longitudinal analysis of nine cohorts. Lancet Neurol 16:620-629
Liu, Ganqiang; Boot, Brendon; Locascio, Joseph J et al. (2016) Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's. Ann Neurol 80:674-685
Locascio, Joseph J; Eberly, Shirley; Liao, Zhixiang et al. (2015) Association between ?-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease. Brain 138:2659-71
Tanner, Caroline M; Meng, Cheryl C; Ravina, Bernard et al. (2014) A practical approach to remote longitudinal follow-up of Parkinson's disease: the FOUND study. Mov Disord 29:743-9
Videnovic, Aleksandar; Noble, Charleston; Reid, Kathryn J et al. (2014) Circadian melatonin rhythm and excessive daytime sleepiness in Parkinson disease. JAMA Neurol 71:463-9
Lang, Anthony E; Eberly, Shirley; Goetz, Christopher G et al. (2013) Movement disorder society unified Parkinson disease rating scale experiences in daily living: longitudinal changes and correlation with other assessments. Mov Disord 28:1980-6
Tsanas, Athanasios; Little, Max A; McSharry, Patrick E et al. (2012) Statistical analysis and mapping of the Unified Parkinson's Disease Rating Scale to Hoehn and Yahr staging. Parkinsonism Relat Disord 18:697-9
Ravina, Bernard; Marek, Kenneth; Eberly, Shirley et al. (2012) Dopamine transporter imaging is associated with long-term outcomes in Parkinson's disease. Mov Disord 27:1392-7
Saunders-Pullman, Rachel; Cabassa, Jose; San Luciano, Marta et al. (2011) LRRK2 G2019S mutations may be increased in Puerto Ricans. Mov Disord 26:1772-3
Brüggemann, Norbert; Hagenah, Johann; Stanley, Kaili et al. (2011) Substantia nigra hyperechogenicity with LRRK2 G2019S mutations. Mov Disord 26:885-8

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