""""""""Discovery of natural product-based drugs from Costa Rican Biota"""""""" is a consortium of researchers from academia and industry organized in response to a RFA to form an International Cooperative Biodiversity Group (ICBG). Significant progress was made during an R21-supported planning phase. The ICBG described in this proposal involves programs located in the US and Costa Rica that will cooperate to: improve human health through the discovery of bioactive natural products from Costa Rica's rich biodiversity, focus the natural product search on unexplored and under explored microorganisms such as marine bacteria, environmental DMA, endophytic fungi, and myxobacteria, and improve the research capacity and economic opportunities for Costa Rica and contribute to its National Biodiversity Strategy through gathering data for its biodiversity inventory, intensive screening of its natural products in medically relevant assays, sharing of resources, clear benefit-sharing, and training of students and visiting scientists. These broad aims will be carried out by four Associate Programs. AP1, entitled Screening and Informatics, is at Harvard Medical School; AP2, entitled From Unique Sources to Microorganisms: Inventory and Bioprospecting in Costa Rica, is at the National Institute of Biodiversity (INBio) in Costa Rica; APS, entitled Harnessing Secondary Metabolic Pathways from Microbial Systems, is at the University of Michigan; and AP4, entitled Chemistry and Environmental DNA, is also at the Harvard Medical School. These four programs have a highly integrated work plan, and the three institutions have reached an agreement in principle on intellectual property and benefit sharing. Several training and capacity building aspects are also incorporated in the plan. / Natural products have been the single greatest source of medically useful small molecules, and this ICBG by exploring new sources, using a large number of biological assays, and having an industrial development partner, has an excellent chance of finding additional medically useful small molecules. ? ?

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01TW007404-01
Application #
7022408
Study Section
Special Emphasis Panel (ZRG1-ICP-2 (50))
Program Officer
Katz, Flora N
Project Start
2005-09-29
Project End
2009-08-31
Budget Start
2005-09-29
Budget End
2006-08-31
Support Year
1
Fiscal Year
2005
Total Cost
$859,754
Indirect Cost
Name
Harvard University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code
02115
Mike, Laura A; Tripathi, Ashootosh; Blankenship, Connor M et al. (2017) Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments. Chem Commun (Camb) 53:12778-12781
Park, Sung Ryeol; Tripathi, Ashootosh; Wu, Jianfeng et al. (2016) Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway. Nat Commun 7:10710
Cheng, Ken Chih-Chien; Cao, Shugeng; Raveh, Avi et al. (2015) Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts. J Nat Prod 78:2411-22
Schofield, Michael M; Jain, Sunit; Porat, Daphne et al. (2015) Identification and analysis of the bacterial endosymbiont specialized for production of the chemotherapeutic natural product ET-743. Environ Microbiol 17:3964-75
Lowell, Andrew N; Santoro, Nicholas; Swaney, Steven M et al. (2015) Microscale Adaptation of In Vitro Transcription/Translation for High-Throughput Screening of Natural Product Extract Libraries. Chem Biol Drug Des 86:1331-8
Negretti, Solymar; Narayan, Alison R H; Chiou, Karoline C et al. (2014) Directing group-controlled regioselectivity in an enzymatic C-H bond oxygenation. J Am Chem Soc 136:4901-4
Vargas-Asensio, Gabriel; Pinto-Tomas, Adrian; Rivera, Beatriz et al. (2014) Uncovering the cultivable microbial diversity of costa rican beetles and its ability to break down plant cell wall components. PLoS One 9:e113303
Coates, R Cameron; Podell, Sheila; Korobeynikov, Anton et al. (2014) Characterization of cyanobacterial hydrocarbon composition and distribution of biosynthetic pathways. PLoS One 9:e85140
Raveh, Avi; Schultz, Pamela J; Aschermann, Lauren et al. (2014) Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts. Mol Pharmacol 86:406-16
Tripathi, Ashootosh; Schofield, Michael M; Chlipala, George E et al. (2014) Baulamycins A and B, broad-spectrum antibiotics identified as inhibitors of siderophore biosynthesis in Staphylococcus aureus and Bacillus anthracis. J Am Chem Soc 136:1579-86

Showing the most recent 10 out of 35 publications