The primary objectives of this research project are: 1) to extend our knowledge of the natural history of choroidal neovascular membranes in eyes with ocular histoplasmosis, senile macular degeneration and idiopathic macular degeneration, 2) to improve our information on the natural history of pre-existing chorioretinal scars in ocular histoplasmosis and macular drusen in senile macular degeneration, 3) to observe the rate of development of new chorioretinal scars in ocular histoplasmosis, and 4) to determine whether obliteration of choroidal neovascular membranes using argon laser photocoagulation is useful in preserving visual acuity in patients with ocular histoplasmosis, senile macular degeneration or idiopathic macular degeneration. Appropriate patients will be assigned to treatment or non-treatment categories by a randomized allocation process.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10EY002553-15
Application #
3559082
Study Section
Vision Research and Training Committee (VSN)
Project Start
1979-01-15
Project End
1993-12-31
Budget Start
1993-01-01
Budget End
1993-12-31
Support Year
15
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Iowa
Department
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Jefferys, Joan L; Alexander, Judith; Hiner, Cheryl J et al. (2008) Reproducibility of gradings of retinal photographs in eyes with subfoveal choroidal neovascularization and age-related macular degeneration in the macular photocoagulation study. Ophthalmic Epidemiol 15:191-201
(1991) Laser photocoagulation of subfoveal recurrent neovascular lesions in age-related macular degeneration. Results of a randomized clinical trial. Macular Photocoagulation Study Group. Arch Ophthalmol 109:1232-41
(1991) Argon laser photocoagulation for neovascular maculopathy. Five-year results from randomized clinical trials. Macular Photocoagulation Study Group. Arch Ophthalmol 109:1109-14
(1991) Laser photocoagulation of subfoveal neovascular lesions in age-related macular degeneration. Results of a randomized clinical trial. Macular Photocoagulation Study Group. Arch Ophthalmol 109:1220-31
(1991) Subfoveal neovascular lesions in age-related macular degeneration. Guidelines for evaluation and treatment in the macular photocoagulation study. Macular Photocoagulation Study Group. Arch Ophthalmol 109:1242-57
(1990) Krypton laser photocoagulation for idiopathic neovascular lesions. Results of a randomized clinical trial. Macular Photocoagulation Study Group. Arch Ophthalmol 108:832-7
Bressler, S B; Maguire, M G; Bressler, N M et al. (1990) Relationship of drusen and abnormalities of the retinal pigment epithelium to the prognosis of neovascular macular degeneration. The Macular Photocoagulation Study Group. Arch Ophthalmol 108:1442-7
(1990) Persistent and recurrent neovascularization after krypton laser photocoagulation for neovascular lesions of age-related macular degeneration. Macular Photocoagulation Study Group. Arch Ophthalmol 108:825-31
(1989) Persistent and recurrent neovascularization after krypton laser photocoagulation for neovascular lesions of ocular histoplasmosis. Macular Photocoagulation Study Group. Arch Ophthalmol 107:344-52
Blackhurst, D W; Maguire, M G (1989) Reproducibility of refraction and visual acuity measurement under a standard protocol. The Macular Photocoagulation Study Group. Retina 9:163-9