This application proposes that the Maternal-Fetal Medicine Unit of the University of Cincinnati Medical Center (UCMC) be selected for the Cooperative Multicenter Network of Maternal-Fetal Medicine Units (MFMUs). The Maternal-Fetal Medicine Unit of the University of Cincinnati Medical Center is particularly well suited for collaboration and cooperation with other Maternal-Fetal Medicine units and with NICHD staff to establish research protocols, uniform data formats, and data transfer. The Maternal-Fetal Medicine Unit at the University of Cincinnati has demonstrated an excellent tradition of close cooperation among Neonatology, Endocrinology, Biostatistics and Epidemiology during the planning and implementation of the Diabetes in Pregnancy Program Project Grant, the NIH Perinatal Emphasis Research Center for the study of intrauterine growth retardation, and the Perinatal Research Institute. Over 2600 primary and referred patients are delivered at the MFMU of UCMC each year with greater than 40% being high risk, 51% white and 20% private. Professional staffing of the MFMU of UCMC is provided 24 hours a day by four board certified or eligible MFM specialists and five MFM fellows. Multidisciplinary cooperation for perinatal care includes neonatal care, genetics, internal medicine, laboratory medicine and social services. Level I and II obstetrical ultrasound, antenatal testing, and sophisticated laboratory analysis are available to the MFMU 24 hours/day. Previous and ongoing experience in multidisciplinary clinical research trials including complex data formatting, entry, and analysis assures valuable contributions by the MFMU of UCMC to the Cooperative Multicenter Network of MFMUs. The Maternal-Fetal Medicine faculty and services at UCMC are complemented by a nationally renowned Neonatal faculty committed to the concept that important and unresolved issues of perinatal care can only be solved by carefully planned prospective clinical trials. Not only do the two faculty enjoy strong clinical, research and training links, the Greater Cincinnati Metropolitan region is unique in that there is well established and successful Perinatal-Neonatal Outreach Program which ensures referral of all complicated pregnancies to the MFMU at UCMC. The commitment of UCMC and the Childrens' Hospital Medical Center (CHMC) to research is further exemplified by the creation four years ago of the 35 investigator Perinatal Research Institute whose efforts are exclusively devoted to perinatal and developmental research.

Project Start
1991-04-01
Project End
1996-03-31
Budget Start
1992-04-01
Budget End
1993-03-31
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Cincinnati
Department
Type
Schools of Medicine
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Clark, Erin A S; Weiner, Steven J; Rouse, Dwight J et al. (2018) Genetic Variation, Magnesium Sulfate Exposure, and Adverse Neurodevelopmental Outcomes Following Preterm Birth. Am J Perinatol 35:1012-1022
Landon, Mark B; Grobman, William A; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network (2016) What We Have Learned About Trial of Labor After Cesarean Delivery from the Maternal-Fetal Medicine Units Cesarean Registry. Semin Perinatol 40:281-6
Wapner, Ronald J; Gyamfi-Bannerman, Cynthia; Thom, Elizabeth A et al. (2016) What we have learned about antenatal corticosteroid regimens. Semin Perinatol 40:291-7
Caritis, Steve N; Feghali, Maisa N; Grobman, William A et al. (2016) What we have learned about the role of 17-alpha-hydroxyprogesterone caproate in the prevention of preterm birth. Semin Perinatol 40:273-80
Olson, Gayle; Weiner, Steven J; Rouse, Dwight J et al. (2015) Relation between birth weight and weight and height at the age of 2 in children born preterm. Am J Perinatol 32:591-8
Hirtz, Deborah G; Weiner, Steven J; Bulas, Dorothy et al. (2015) Antenatal Magnesium and Cerebral Palsy in Preterm Infants. J Pediatr 167:834-839.e3
Horton, Amanda L; Lai, Yinglei; Rouse, Dwight J et al. (2015) Effect of magnesium sulfate administration for neuroprotection on latency in women with preterm premature rupture of membranes. Am J Perinatol 32:387-92
Borowski, K S; Clark, E A S; Lai, Y et al. (2015) Neonatal Genetic Variation in Steroid Metabolism and Key Respiratory Function Genes and Perinatal Outcomes in Single and Multiple Courses of Corticosteroids. Am J Perinatol 32:1126-32
Peaceman, Alan M; Lai, Yinglei; Rouse, Dwight J et al. (2015) Length of latency with preterm premature rupture of membranes before 32 weeks' gestation. Am J Perinatol 32:57-62
Varner, Michael W; Marshall, Nicole E; Rouse, Dwight J et al. (2015) The association of cord serum cytokines with neurodevelopmental outcomes. Am J Perinatol 30:115-22

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