In order to improve outcomes for newborn infants by generating scientific evidence on which to base clinical management, the Joint Program in Neonatology (JPN) seeks to join the Cooperative Multicenter Neonatal Research Network. The JPN is a unified group of Harvard Medical School faculty members who provide clinical care, research, and training in newborn medicine. In modern and well-equipped NICUs at Brigham and Women's (BWH), Beth Israel (BI), and Children's (CH) Hospitals, 82 beds accommodate nearly 2000 admissions per year, of which 80% are inborn. A well-defined administrative infrastructure unites our program, ensuring uniformity of clinical practice and the rigorous implementation of research protocols. Supervised by JPN Director Dr. Merton Bernfield and Clinical Director Dr. Ann Stark, the JPN is also linked by its Infant Follow-up Program, database, and fellowship training program. The JPN works closely with obstetrical services at BWH and BI, with combined annual deliveries of nearly 14,000. CH specialists provide consultative support in all JPN MCUs and collaborate in many investigations. Research strengths derive from the depth and diversity of academic interests within the JPN that are concentrated in perinatal epidemiology, developmental biology, and clinical investigation. The JPN's experience in clinical investigation in our MCUs and follow-up program demonstrates the ability to identify and investigate priority research areas and to collaborate both within and outside of Harvard. JPN faculty provide direct links to Harvard Medical area resources including Harvard School of Public Health, CH Enders Pediatric Research Laboratories, CH General Clinical Research Center, and the CH Department of Neurology. With a faculty experienced in clinical care and investigation, the academic resources of the Harvard medical area, and an administrative infrastructure linking the large population of three MCUs and an infant follow-up program, the JPN is eager to participate in the Network and contribute to its research productivity, thereby improving the health of newborns.

Project Start
1996-05-06
Project End
2001-03-31
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Stoll, Barbara J; Hansen, Nellie I; Bell, Edward F et al. (2015) Trends in Care Practices, Morbidity, and Mortality of Extremely Preterm Neonates, 1993-2012. JAMA 314:1039-51
Stark, Ann R; Carlo, Waldemar A; Vohr, Betty R et al. (2014) Death or neurodevelopmental impairment at 18 to 22 months corrected age in a randomized trial of early dexamethasone to prevent death or chronic lung disease in extremely low birth weight infants. J Pediatr 164:34-39.e2
Wadhawan, Rajan; Oh, William; Vohr, Betty R et al. (2013) Spontaneous intestinal perforation in extremely low birth weight infants: association with indometacin therapy and effects on neurodevelopmental outcomes at 18-22 months corrected age. Arch Dis Child Fetal Neonatal Ed 98:F127-32
Konduri, G G; Sokol, G M; Van Meurs, K P et al. (2013) Impact of early surfactant and inhaled nitric oxide therapies on outcomes in term/late preterm neonates with moderate hypoxic respiratory failure. J Perinatol 33:944-9
Wyckoff, Myra H; Salhab, Walid A; Heyne, Roy J et al. (2012) Outcome of extremely low birth weight infants who received delivery room cardiopulmonary resuscitation. J Pediatr 160:239-244.e2
Carlo, Waldemar A; McDonald, Scott A; Fanaroff, Avroy A et al. (2011) Association of antenatal corticosteroids with mortality and neurodevelopmental outcomes among infants born at 22 to 25 weeks' gestation. JAMA 306:2348-58
Boghossian, Nansi S; Hansen, Nellie I; Bell, Edward F et al. (2010) Survival and morbidity outcomes for very low birth weight infants with Down syndrome. Pediatrics 126:1132-40
Stark, A R; Tyson, J E; Hibberd, P L (2010) Variation among institutional review boards in evaluating the design of a multicenter randomized trial. J Perinatol 30:163-9
Wadhawan, Rajan; Oh, William; Perritt, Rebecca L et al. (2009) Twin gestation and neurodevelopmental outcome in extremely low birth weight infants. Pediatrics 123:e220-7
Da Costa, David; Bann, Carla M; Hansen, Nellie I et al. (2009) Validation of the Functional Status II questionnaire in the assessment of extremely-low-birthweight infants. Dev Med Child Neurol 51:536-44

Showing the most recent 10 out of 49 publications