Pediatric Critical Care Medicine Incorporates a multidisciplinary approach to address the medical needs of the most fragile population of critically III and Injured children. Fortunately, improvements in care over the past decades have impacted mortality for all PICU patients such that current annual rates at most academic, tertiary care centers are below 5%. However, certain disease processes notably acute lung injury and sepsis, remain associated with significantly higher mortality rates as well as consume substantial health care resources. Despite this, the occurrences of these most challenging diseases do not occur sufficiently often at any one center to enable an effective, single-site study that will advance both our understanding and management of these diseases. Mindful of this reality, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) showed great wisdom in funding an infrastructure to address the need to create a multi-center research network, the Collaborative Pediatric Critical Care Research Network (CPCCRN). Our rapidly evolving program at the University of Michigan has made great strides in establishing a local Infrastructure to allow us to actively participate in a number of network-base studies. In addition to possessing this infrastructure capacity, we also believe we have a team of investigators who can make important scientific and leadership contributions to this network. As a result, we are applying to become a participating site within CPCCRN to assistant in executing investigations of pathobiology, management strategies, and the safety and efficacy of treatments for critically ill or injured children. As part of this application, we have submitted a Concept Proposal which reflects both our Infrastructure and Intellectual capacity to contribute in a productive manner to CPCCRN. We hypothesize that an Improved understanding of the mechanisms regulating gene expression associated with host Immune dysfunction In the late phase of critical Illnesses will identify novel therapeutic targets for further improving outcomes.

Public Health Relevance

This concept study is a reflection of our program's overall goal to contribute in a meaningful way to the on-going growth and success of a research network that is committed to improving both the short- and long-term outcomes of critically ill and injured children.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10HD063106-02
Application #
8010170
Study Section
Special Emphasis Panel (ZHD1-DSR-A (25))
Program Officer
Nicholson, Carol E
Project Start
2009-12-24
Project End
2014-11-30
Budget Start
2010-12-01
Budget End
2011-11-30
Support Year
2
Fiscal Year
2011
Total Cost
$255,317
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Pediatrics
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Pollack, Murray M; Holubkov, Richard; Berg, Robert A et al. (2018) Predicting cardiac arrests in pediatric intensive care units. Resuscitation 133:25-32
Cashen, Katherine; Reeder, Ron; Dalton, Heidi J et al. (2018) Acquired infection during neonatal and pediatric extracorporeal membrane oxygenation. Perfusion 33:472-482
Berg, Robert A; Sutton, Robert M; Reeder, Ron W et al. (2018) Association Between Diastolic Blood Pressure During Pediatric In-Hospital Cardiopulmonary Resuscitation and Survival. Circulation 137:1784-1795
Cashen, Katherine; Reeder, Ron W; Shanti, Christina et al. (2018) Is therapeutic hypothermia during neonatal extracorporeal membrane oxygenation associated with intracranial hemorrhage? Perfusion 33:354-362
Sutton, Robert M; Reeder, Ron W; Landis, William et al. (2018) Chest compression rates and pediatric in-hospital cardiac arrest survival outcomes. Resuscitation 130:159-166
Muszynski, Jennifer A; Reeder, Ron W; Hall, Mark W et al. (2018) RBC Transfusion Practice in Pediatric Extracorporeal Membrane Oxygenation Support. Crit Care Med 46:e552-e559
Dalton, Heidi J; Cashen, Katherine; Reeder, Ron W et al. (2018) Hemolysis During Pediatric Extracorporeal Membrane Oxygenation: Associations With Circuitry, Complications, and Mortality. Pediatr Crit Care Med 19:1067-1076
Berger, John T; Villalobos, Michele E; Clark, Amy E et al. (2018) Cognitive Development One Year After Infantile Critical Pertussis. Pediatr Crit Care Med 19:89-97
Basu, Sonali; Holubkov, Richard; Dean, J Michael et al. (2018) PICU Autopsies: Rates, Patient Characteristics, and the Role of the Medical Examiner. Pediatr Crit Care Med 19:1137-1145
Berg, Robert A; Reeder, Ron W; Meert, Kathleen L et al. (2018) End-tidal carbon dioxide during pediatric in-hospital cardiopulmonary resuscitation. Resuscitation 133:173-179

Showing the most recent 10 out of 39 publications