Abstract

Our Network proposes to carry out five specific aims to localize and characterize the genetic determinants of high BP.
Aim I will use robust sibling pair linkage methods in 500 hypertensive sibling pairs in each racial group (a total of 1,500 sibling pairs) to localize genes influencing interindividual differences in the occurrence of Essential Hypertension.
Aims 2 and 3 will take advantage of previously collected BP and intermediate predictor trait data from 1,488 normotensive sibling pairs from the Rochester Family Heart Study to localize genes contributing to Essential Hypertension. The proposed linkage analyses (Aims 1-3) will use both an extensive array of candidate genes and a large number of anonymous markers throughout the genome.
Aim 4 will use multiple diallelic sequence polymorphisms and cladistic analyses within a linked gene to identify haplotypes for further DNA sequencing in order to identity ca date functional DNA sequence variation contributing to interindividual differences in BP levels and Essential Hypertension status.
Aim 5 will evaluate the ability of candidate functional DNA sequence variation to predict Essential Hypertension status in three racial groups.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10HL054504-04
Application #
2771436
Study Section
Special Emphasis Panel (ZHL1-CCT-M (F2))
Project Start
1995-09-05
Project End
2000-08-31
Budget Start
1998-09-18
Budget End
1999-08-31
Support Year
4
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of Texas Health Science Center Houston
Department
Genetics
Type
Schools of Public Health
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225

  Publications

Fox, Ervin R; Klos, Kathy L; Penman, Alan D et al. (2010) Heritability and genetic linkage of left ventricular mass, systolic and diastolic function in hypertensive African Americans (From the GENOA Study). Am J Hypertens 23:870-5
Montasser, May E; Shimmin, Lawrence C; Hanis, Craig L et al. (2009) Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans. J Hypertens 27:491-501
Aguilar, David; Hallman, D Michael; Piller, Linda B et al. (2009) Adverse association between diabetic retinopathy and cardiac structure and function. Am Heart J 157:563-8
Kraja, Aldi T; Rao, Dabeeru C; Weder, Alan B et al. (2005) Two major QTLs and several others relate to factors of metabolic syndrome in the family blood pressure program. Hypertension 46:751-7