: Cardiovascular (CV) disease remains the nation's #1 deadliest medical condition while CV care remains far from ideal and CV care costs are among the most expensive. The safety and effectiveness of many CV drugs and devices are uncertain in certain patient populations and in community settings, and there is ample evidence of under-, over- and mis-use of such agents. To address these issues, the Duke Clinical Research Institute (DCRI) has established a broad set of alliances with all of the major CV professional societies. These collaborations provide us with an unprecedented opportunity to evaluate 'real world' safety, effectiveness and efficiency of CV therapeutics, but also the means to translate knowledge gained into practice; with an ultimate goal of improving patient outcomes on a national scale. Our proposal also addresses CV therapeutics across the continuum; from in-patient settings to issues of long-term patient adherence; and for five major CV emphasis areas including: acute coronary syndromes; heart failure; stroke; sudden cardiac death; and coronary revascularization. This proposal is dedicated to advancing the state of the science of post-market CV drug and device evaluation and quality improvement, but also to generating practical and actionable information and products for clinicians, policy makers, and the public. Our Duke CERTs Specific Aims are to: ? 1. Promote the optimization of professional society-led CV registries as national surveillance systems for evaluating and assuring the safety and effectiveness of CV therapeutics and devices in community based settings; and meeting the informational needs of FDA, CMS, NIH, and AHRQ. ? 2. Identify specific barriers to both the translation of CV therapeutic and device evidence into routine ? clinical practice and long-term patient adherence to effective CV therapeutics. ? 3. Develop and rigorously evaluate patient- and provider-based interventions designed to improve the ? safe, effective, and efficient use of CV therapies and to improve long-term treatment adherence. ? 4. Widely disseminate those interventions found to be effective. ? 5. Train the next generation of CV outcomes researchers. ? ? ? ?

Agency
National Institute of Health (NIH)
Institute
Agency for Healthcare Research and Quality (AHRQ)
Type
Research Demonstration--Cooperative Agreements (U18)
Project #
5U18HS016964-02
Application #
7490911
Study Section
Special Emphasis Panel (ZHS1-HSR-O (01))
Program Officer
Sedrakyan, Artyom
Project Start
2007-09-01
Project End
2011-08-31
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
2
Fiscal Year
2008
Total Cost
Indirect Cost
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Fonarow, Gregg C; Liang, Li; Thomas, Laine et al. (2016) Assessment of Home-Time After Acute Ischemic Stroke in Medicare Beneficiaries. Stroke 47:836-42
Lin, Cheryl B; Cox, Margueritte; Olson, DaiWai M et al. (2015) Perception Versus Actual Performance in Timely Tissue Plasminogen Activation Administration in the Management of Acute Ischemic Stroke. J Am Heart Assoc 4:
Bettger, Janet Prvu; Zhao, Xin; Bushnell, Cheryl et al. (2014) The association between socioeconomic status and disability after stroke: findings from the Adherence eValuation After Ischemic stroke Longitudinal (AVAIL) registry. BMC Public Health 14:281
Olson, DaiWai M; Cox, Margueritte; Constable, Mark et al. (2014) Development and initial testing of the stroke rapid-treatment readiness tool. J Neurosci Nurs 46:267-73
Xian, Ying; Chen, Anita Y; Thomas, Laine et al. (2014) Sources of hospital-level variation in major bleeding among patients with non-st-segment elevation myocardial infarction: a report from the National Cardiovascular Data Registry (NCDR). Circ Cardiovasc Qual Outcomes 7:236-43
Bushnell, Cheryl D; Reeves, Mathew J; Zhao, Xin et al. (2014) Sex differences in quality of life after ischemic stroke. Neurology 82:922-31
Olson, Daiwai M; Cox, Margueritte; Pan, Wenqin et al. (2013) Death and rehospitalization after transient ischemic attack or acute ischemic stroke: one-year outcomes from the adherence evaluation of acute ischemic stroke-longitudinal registry. J Stroke Cerebrovasc Dis 22:e181-8
Kociol, Robb D; Liang, Li; Hernandez, Adrian F et al. (2013) Are we targeting the right metric for heart failure? Comparison of hospital 30-day readmission rates and total episode of care inpatient days. Am Heart J 165:987-994.e1
Hernandez, Adrian F (2013) Preventing heart failure. JAMA 310:44-5
Thomas, Kevin L; Zimmer, Louise O; Dai, David et al. (2013) Educational videos to reduce racial disparities in ICD therapy via innovative designs (VIVID): a randomized clinical trial. Am Heart J 166:157-63

Showing the most recent 10 out of 42 publications