The Andean CIPRA U19 proposal represents a consortium of researchers, primarily from the Peruvian research NGO, Impacta Salud y Educacion, from the School of Public Health at Universidad Peruana Cayetano Heredia and from the US Naval Medical Research Center Detachment and the U. of Washington and the U. of California San Francisco CFAR-affiliated faculty are partners in the proposal. The theme of this CIPRA is Pathogenesis, Prevention, and Treatment of HIV in the Andean Region. The overall aims of the Andean CIPRA are to: 1) Further develop regional, institutional, and investigator capacity for HIV prevention, vaccine and treatment research through Core A: Administrative and developmental (which includes a community education and development sub-core); Core B: Biostatistics, Data Management and Informatics; Core C: Laboratory; and Core D: Research Development and Training; and to 2) Support specific research projects of particular importance to the Andean region. The Andean CIPRA will directly support three major research projects and developmental projects. The major research projects proposed build on four recently funded HIV research programs in Peru: the NIH-funded HPTN, HVTN, and IACTG Units, and a community randomized trial (CRT), funded by Wellcome Trust and by USAID-Peru, of a hybrid STD/HIV Prevention Intervention. Project 1 will quantify the increase in anorectal and cervical HIV shedding associated with HSV-2 reactivation among HIV and HSV co-infected men and women, and will assess the reduction in genital HIV shedding with daily suppressive acyclovir; Project 2 will test immunologic and virologic outcomes, adherence, and rate of emergence of ARV resistance with a once daily antiretroviral regimen in HIV (+) persons, comparing directly-observed vs. self-directed therapy in the first 6 months of ARV initiation, and comparing intensive vs. less intensive laboratory monitoring; Project 3 will evaluate repeated cross-sectional sampling of high risk, bridging, and low risk urban populations to assess population-level impact of the hybrid intervention CRT, and to monitor the impact of Peru's new $29 million Global Health Fund program on antiretroviral resistance of HIV, on risk behaviors and incidence of HIV; and will conduct multilevel analyses of risk determinants for HIV and STD infections at the level, and of the impact of behavioral and biologic interventions on STD and HIV infection rates. The Andean CIPRA has an External Advisory Committee of experts and collaborators from other Andean countries, and the U.S. [An Andean CIPRA coordination system based upon three pronged branches (the Andean government's health coordination system, the Pan American Health organization, and existing HIV research networks) will be use for expanding CIPRA activities.]

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI053218-01A2
Application #
6785640
Study Section
Special Emphasis Panel (ZAI1-EC-A (S6))
Program Officer
Ruiz, Monica S
Project Start
2004-09-30
Project End
2007-08-31
Budget Start
2004-09-30
Budget End
2005-08-31
Support Year
1
Fiscal Year
2004
Total Cost
$1,000,000
Indirect Cost
Name
Asociacion Civil Impacta Salud Y Educacn
Department
Type
DUNS #
934348053
City
Lima
State
Country
Peru
Zip Code
LIMA -04
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Campos, Pablo E; Buffardi, Anne L; Cárcamo, César P et al. (2013) Reaching the unreachable: providing STI control services to female sex workers via mobile team outreach. PLoS One 8:e81041
Orellana, E Roberto; Alva, Isaac E; Cárcamo, Cesar P et al. (2013) Structural factors that increase HIV/STI vulnerability among indigenous people in the Peruvian amazon. Qual Health Res 23:1240-50
García, Patricia J; Holmes, King K; Cárcamo, César P et al. (2012) Prevention of sexually transmitted infections in urban communities (Peru PREVEN): a multicomponent community-randomised controlled trial. Lancet 379:1120-8
Garcia, Patricia J; Carcamo, Cesar P; Garnett, Geoff P et al. (2012) Improved STD syndrome management by a network of clinicians and pharmacy workers in Peru: The PREVEN Network. PLoS One 7:e47750
Grinsztejn, Beatriz; Smeaton, Laura; Barnett, Ronald et al. (2011) Sex-associated differences in pre-antiretroviral therapy plasma HIV-1 RNA in diverse areas of the world vary by CD4(+) T-cell count. Antivir Ther 16:1057-62
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Gomez, Gabriela B; Campos, Pablo E; Buendia, Clara et al. (2010) Studying complex interactions among determinants of healthcare-seeking behaviours: self-medication for sexually transmitted infection symptoms in female sex workers. Sex Transm Infect 86:285-91
Bernabe-Ortiz, Antonio; White, Peter J; Carcamo, Cesar P et al. (2009) Clandestine induced abortion: prevalence, incidence and risk factors among women in a Latin American country. CMAJ 180:298-304
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